We have determined the nucleotide sequence of the Dictyostelium discoideum 5.8S ribosomal RNA (rRNA). The sequence has relatively low homology with other 5.8S rRNAs and is further distinguished by its lack of modified nucleotides. The homology data indicate that D. discoideum diverged from the mainstream of eukaryotic descent at the earliest branch yet characterized by molecular phylogeny. Taking advantage of the considerable divergence of the D.
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