Nucleophile substituted ecteinascidins and N-oxide ecteinascidins

Kenneth L. Rinehart (Inventor), Tong Zhou (Inventor)

Research output: Patent


Five new nucleophile substituted ecteinascidin (Et) compounds have been isolated from extracts of Ecteinascidia turbinata. These compounds have been purified by chromatographic techniques and their structures and bioactivities have been determined. The five nucleophile substituted Et compounds have been designated herein as Et 802 (1), Et 788 (2), Et 760 (3), Et 858 (4) and Et 815 (5). Also obtained were three new N-oxide ecteinascidin compounds, which have been designated herein as Et 717 (6), Et 775 (7) and Et 789 (8). Some of these newly discovered Et compounds show exceedingly potent cytotoxicity against L1210.
Original languageEnglish (US)
U.S. patent number5985876
Filing date4/10/98
StatePublished - Nov 16 1999

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