Nuclear hormone receptors: Ligand-activated regulators of transcription and diverse cell responses

John A. Katzenellenbogen, Benita S Katzenellenbogen

Research output: Contribution to journalReview article

Abstract

Signal transduction via nuclear hormone receptors is unusual in that the hormone ligand forms an integral part of the protein complex involved in DNA binding and transcriptional activation. New structural and biochemical results have begun to unravel how these receptors produce different effects in different cells, and the structural changes involved in transcriptional activation.

Original languageEnglish (US)
Pages (from-to)529-536
Number of pages8
JournalChemistry and Biology
Volume3
Issue number7
DOIs
StatePublished - Jul 1996

Fingerprint

Transcription
Cytoplasmic and Nuclear Receptors
Transcriptional Activation
Chemical activation
Ligands
Signal transduction
Signal Transduction
Hormones
DNA
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

Nuclear hormone receptors : Ligand-activated regulators of transcription and diverse cell responses. / Katzenellenbogen, John A.; Katzenellenbogen, Benita S.

In: Chemistry and Biology, Vol. 3, No. 7, 07.1996, p. 529-536.

Research output: Contribution to journalReview article

@article{0a217fcf7dab4abc91c6f607dcf95a33,
title = "Nuclear hormone receptors: Ligand-activated regulators of transcription and diverse cell responses",
abstract = "Signal transduction via nuclear hormone receptors is unusual in that the hormone ligand forms an integral part of the protein complex involved in DNA binding and transcriptional activation. New structural and biochemical results have begun to unravel how these receptors produce different effects in different cells, and the structural changes involved in transcriptional activation.",
author = "Katzenellenbogen, {John A.} and Katzenellenbogen, {Benita S}",
year = "1996",
month = "7",
doi = "10.1016/S1074-5521(96)90143-X",
language = "English (US)",
volume = "3",
pages = "529--536",
journal = "Cell Chemical Biology",
issn = "2451-9448",
publisher = "Elsevier Inc.",
number = "7",

}

TY - JOUR

T1 - Nuclear hormone receptors

T2 - Ligand-activated regulators of transcription and diverse cell responses

AU - Katzenellenbogen, John A.

AU - Katzenellenbogen, Benita S

PY - 1996/7

Y1 - 1996/7

N2 - Signal transduction via nuclear hormone receptors is unusual in that the hormone ligand forms an integral part of the protein complex involved in DNA binding and transcriptional activation. New structural and biochemical results have begun to unravel how these receptors produce different effects in different cells, and the structural changes involved in transcriptional activation.

AB - Signal transduction via nuclear hormone receptors is unusual in that the hormone ligand forms an integral part of the protein complex involved in DNA binding and transcriptional activation. New structural and biochemical results have begun to unravel how these receptors produce different effects in different cells, and the structural changes involved in transcriptional activation.

UR - http://www.scopus.com/inward/record.url?scp=0030199294&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030199294&partnerID=8YFLogxK

U2 - 10.1016/S1074-5521(96)90143-X

DO - 10.1016/S1074-5521(96)90143-X

M3 - Review article

C2 - 8807884

AN - SCOPUS:0030199294

VL - 3

SP - 529

EP - 536

JO - Cell Chemical Biology

JF - Cell Chemical Biology

SN - 2451-9448

IS - 7

ER -