Nuclear deformation regulates YAP dynamics in cancer associated fibroblasts

Keyphrases

• Protein Dynamics 100%
• In Cancer 100%
• Cancer-associated Fibroblasts 100%
• Yes-associated Protein 1 (YAP1) 100%
• Nuclear Deformation 100%
• 2D Substrate 15%
• Protein Localization 15%
• Regulatory Mechanism 10%
• Stochastic Model 10%
• Power Law 10%
• Membrane Curvature 10%
• Nuclear Translocation 10%
• Protein Activation 10%
• Stiffness Force 10%
• Protein Kinetics 10%
• Total Force 10%
• Intracellular Forces 10%
• Tumor 5%
• Transcription Factor 5%
• Cell Culture 5%
• Stiffness 5%
• Forced Deformation 5%
• Residence Time 5%
• Human Tumors 5%
• Nuclear Transport 5%
• Clinical Significance 5%
• Valuable Insight 5%
• Mechanical Deformation 5%
• Pro-metastatic 5%
• 3D Environment 5%
• Cancer Progression 5%
• Persistence Time 5%
• Protein Translocation 5%
• Nuclear Membrane 5%
• Induced Membrane 5%
• Potential Biomarkers 5%
• Nuclear Localization 5%
• Threshold Time 5%
• Force Dynamics 5%
• Activation Threshold 5%
• 3D Substrate 5%
• Human Colon Cancer 5%
• Tumor Stiffness 5%
• Cancer Dynamics 5%

Biochemistry, Genetics and Molecular Biology

• Protein Dynamics 100%
• Rigidity 100%
• Fibroblast 100%
• Membrane Curvature 50%
• Nuclear Protein 50%
• Dynamics 25%
• Cell Culture 25%
• Quantitative Technique 25%
• Retention Time 25%
• Transcription 25%
• Nuclear Transport 25%
• Nuclear Membrane 25%
• Colon 25%