Nuclear and extranuclear-initiated estrogen receptor signaling crosstalk and endocrine resistance in breast cancer

Eylem Kulkoyluoglu; Zeynep Madak-Erdogan

doi:10.1016/j.steroids.2016.06.007

Nuclear and extranuclear-initiated estrogen receptor signaling crosstalk and endocrine resistance in breast cancer

Eylem Kulkoyluoglu, Zeynep Madak-Erdogan

Research output: Contribution to journal › Review article › peer-review

Abstract

Estrogens regulate function of reproductive and non-reproductive tissues in healthy and diseased states including breast cancer. They mainly work through estrogen receptor alpha (ERα) and/or estrogen receptor beta (ERβ). There are various ERα targeting agents that have been used for treatment of ER (+) breast tumors. The impact of direct nuclear activity of ER is very well characterized in ER (+) breast cancers and development and progression of endocrine resistance. Recent studies also suggested important roles for extranuclear-initiated ERα pathways, which would decrease the potency and efficiency of ERα targeting agents. In this mini-review, we will discuss the role of nuclear and extra-nuclear ER signaling and how they relate to therapy resistance in breast cancer.

Original language	English (US)
Pages (from-to)	41-47
Number of pages	7
Journal	Steroids
Volume	114
DOIs	https://doi.org/10.1016/j.steroids.2016.06.007
State	Published - 2016

Keywords

Breast cancer
Estrogen receptor
Kinase signaling
Tamoxifen resistance

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Endocrinology
Pharmacology
Clinical Biochemistry
Organic Chemistry

Online availability

10.1016/j.steroids.2016.06.007

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title = "Nuclear and extranuclear-initiated estrogen receptor signaling crosstalk and endocrine resistance in breast cancer",

abstract = "Estrogens regulate function of reproductive and non-reproductive tissues in healthy and diseased states including breast cancer. They mainly work through estrogen receptor alpha (ERα) and/or estrogen receptor beta (ERβ). There are various ERα targeting agents that have been used for treatment of ER (+) breast tumors. The impact of direct nuclear activity of ER is very well characterized in ER (+) breast cancers and development and progression of endocrine resistance. Recent studies also suggested important roles for extranuclear-initiated ERα pathways, which would decrease the potency and efficiency of ERα targeting agents. In this mini-review, we will discuss the role of nuclear and extra-nuclear ER signaling and how they relate to therapy resistance in breast cancer.",

keywords = "Breast cancer, Estrogen receptor, Kinase signaling, Tamoxifen resistance",

author = "Eylem Kulkoyluoglu and Zeynep Madak-Erdogan",

note = "Funding Information: This work was supported by a grant from the National Institute of Food and Agriculture , U.S. Department of Agriculture , award ILLU-698-909 (to ZME). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the U.S. Department of Agriculture. Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

year = "2016",

doi = "10.1016/j.steroids.2016.06.007",

language = "English (US)",

volume = "114",

pages = "41--47",

journal = "Steroids",

issn = "0039-128X",

publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Nuclear and extranuclear-initiated estrogen receptor signaling crosstalk and endocrine resistance in breast cancer

AU - Kulkoyluoglu, Eylem

AU - Madak-Erdogan, Zeynep

N1 - Funding Information: This work was supported by a grant from the National Institute of Food and Agriculture , U.S. Department of Agriculture , award ILLU-698-909 (to ZME). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the U.S. Department of Agriculture. Publisher Copyright: © 2016 Elsevier Inc.

PY - 2016

Y1 - 2016

N2 - Estrogens regulate function of reproductive and non-reproductive tissues in healthy and diseased states including breast cancer. They mainly work through estrogen receptor alpha (ERα) and/or estrogen receptor beta (ERβ). There are various ERα targeting agents that have been used for treatment of ER (+) breast tumors. The impact of direct nuclear activity of ER is very well characterized in ER (+) breast cancers and development and progression of endocrine resistance. Recent studies also suggested important roles for extranuclear-initiated ERα pathways, which would decrease the potency and efficiency of ERα targeting agents. In this mini-review, we will discuss the role of nuclear and extra-nuclear ER signaling and how they relate to therapy resistance in breast cancer.

AB - Estrogens regulate function of reproductive and non-reproductive tissues in healthy and diseased states including breast cancer. They mainly work through estrogen receptor alpha (ERα) and/or estrogen receptor beta (ERβ). There are various ERα targeting agents that have been used for treatment of ER (+) breast tumors. The impact of direct nuclear activity of ER is very well characterized in ER (+) breast cancers and development and progression of endocrine resistance. Recent studies also suggested important roles for extranuclear-initiated ERα pathways, which would decrease the potency and efficiency of ERα targeting agents. In this mini-review, we will discuss the role of nuclear and extra-nuclear ER signaling and how they relate to therapy resistance in breast cancer.

KW - Breast cancer

KW - Estrogen receptor

KW - Kinase signaling

KW - Tamoxifen resistance

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U2 - 10.1016/j.steroids.2016.06.007

DO - 10.1016/j.steroids.2016.06.007

M3 - Review article

C2 - 27394959

AN - SCOPUS:84989182152

SN - 0039-128X

VL - 114

SP - 41

EP - 47

JO - Steroids

JF - Steroids

ER -

Nuclear and extranuclear-initiated estrogen receptor signaling crosstalk and endocrine resistance in breast cancer

Abstract

Keywords

ASJC Scopus subject areas

Online availability

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