Novel rhodamine derivatives as fluorogenic substrates for proteinases

Walter F Mangel (Inventor), Steven P Leytus (Inventor), L Lee Melhado (Inventor)

Research output: Patent


The present invention relates to a new class of novel Rhodamine derivatives. These derivatives which are bisamide substitution products are nonfluorescent. Whereas the monoamide substitution products exhibit high fluorescence. Cleavage of a single specified amide bond by bond-specific proteinases will therefore convert the nonfluorescent bisamide derivative into a highly fluorescent monoamide derivative.
Original languageEnglish (US)
U.S. patent number4640893
Filing date9/27/85
StatePublished - Feb 3 1987


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