Abstract

Molecular recognition is generally thought of in terms of bond formation between unique sites on host and complementary guest molecules, but recent studies have revealed new complexities in biological recognition at cell surfaces. Adhesion between cell similarly involves specific interactions between analogous ligands and receptors. Recent force measurements, however, suggest that cell adhesion proteins may bind via multiple interaction sites that can form in a sequential manner. Other studies further show that in some instances, the principal recognition event may not be receptor-ligand docking, but the assembly of a complex pattern of many receptors and ligands.

Original languageEnglish (US)
Pages (from-to)498-505
Number of pages8
JournalCurrent Opinion in Colloid and Interface Science
Volume6
Issue number5-6
DOIs
StatePublished - Dec 19 2001

Fingerprint

adhesion
Adhesion
Cell adhesion
Ligands
ligands
cells
Molecular recognition
Force measurement
assembly
interactions
proteins
Proteins
Molecules
molecules

Keywords

  • Cadherin
  • Cell adhesion
  • Force measurements
  • Recognition
  • Self-assembly
  • Synapse

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Surfaces and Interfaces

Cite this

Novel recognition mechanisms in biological adhesion. / Leckband, Deborah E.

In: Current Opinion in Colloid and Interface Science, Vol. 6, No. 5-6, 19.12.2001, p. 498-505.

Research output: Contribution to journalReview article

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AB - Molecular recognition is generally thought of in terms of bond formation between unique sites on host and complementary guest molecules, but recent studies have revealed new complexities in biological recognition at cell surfaces. Adhesion between cell similarly involves specific interactions between analogous ligands and receptors. Recent force measurements, however, suggest that cell adhesion proteins may bind via multiple interaction sites that can form in a sequential manner. Other studies further show that in some instances, the principal recognition event may not be receptor-ligand docking, but the assembly of a complex pattern of many receptors and ligands.

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