Novel Liposomal Azido Mannosamine Lipids on Metabolic Cell Labeling and Imaging via Cu-Free Click Chemistry

Li Shen, Kaimin Cai, Jin Yu, Jianjun Cheng

Research output: Contribution to journalArticle

Abstract

In comparison with the popular Ac4ManNAz applied as cell labels via Cu-free click chemistry, two novel azido mannosamine lipids with C6 and C12 esters on anomeric hydroxyl groups were prepared and encapsulated in a liposome delivery system, which enhanced chemical stabilities and showed good cell-metabolizable labeling efficiency on MDA-MB-231 cells with strong fluorescence after the treatment of DBCO-Cy5 by triazole formation via click chemistry.

Original languageEnglish (US)
Pages (from-to)2317-2322
Number of pages6
JournalBioconjugate Chemistry
Volume30
Issue number9
DOIs
StatePublished - Sep 18 2019

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

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