Novel activity of an anti-inflammatory cytokine: IL-10 prevents TNFα-induced resistance to IGF-I in myoblasts

Klemen Strle; Robert H. McCusker; Lynn Tran; Alexandra King; Rodney W. Johnson; Gregory G. Freund; Robert Dantzer; Keith W. Kelley

doi:10.1016/j.jneuroim.2007.05.003

Novel activity of an anti-inflammatory cytokine: IL-10 prevents TNFα-induced resistance to IGF-I in myoblasts

Klemen Strle, Robert H. McCusker, Lynn Tran, Alexandra King, Rodney W. Johnson, Gregory G. Freund, Robert Dantzer, Keith W. Kelley

Research output: Contribution to journal › Article › peer-review

Abstract

IL-10 is an anti-inflammatory cytokine that suppresses synthesis of proinflammatory cytokines and their receptors. Here we tested the possibility that TNFα-induced hormone resistance in myoblasts might be overcome by IL-10. We found that IL-10 restores myogenesis by suppressing the ability of exogenous TNFα to inhibit IGF-I-induced myogenin. This protection occurs without decreasing global activity of TNF receptors since IL-10 does not impair TNFα-induced IL-6 synthesis or ERK1/2 phosphorylation. Instead, IL-10 acts to prevent TNFα-induced phosphorylation of JNK. These findings demonstrate that IL-10 serves a previously unrecognized protective role in muscle progenitors by overcoming TNFα-induced resistance to IGF-I.

Original language	English (US)
Pages (from-to)	48-55
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	188
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2007.05.003
State	Published - Aug 2007
Externally published	Yes

Keywords

Cytokines
Hormone resistance
IGF-I
Inflammation
JNK
Muscle

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

Online availability

10.1016/j.jneuroim.2007.05.003

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title = "Novel activity of an anti-inflammatory cytokine: IL-10 prevents TNFα-induced resistance to IGF-I in myoblasts",

abstract = "IL-10 is an anti-inflammatory cytokine that suppresses synthesis of proinflammatory cytokines and their receptors. Here we tested the possibility that TNFα-induced hormone resistance in myoblasts might be overcome by IL-10. We found that IL-10 restores myogenesis by suppressing the ability of exogenous TNFα to inhibit IGF-I-induced myogenin. This protection occurs without decreasing global activity of TNF receptors since IL-10 does not impair TNFα-induced IL-6 synthesis or ERK1/2 phosphorylation. Instead, IL-10 acts to prevent TNFα-induced phosphorylation of JNK. These findings demonstrate that IL-10 serves a previously unrecognized protective role in muscle progenitors by overcoming TNFα-induced resistance to IGF-I.",

keywords = "Cytokines, Hormone resistance, IGF-I, Inflammation, JNK, Muscle",

author = "Klemen Strle and McCusker, {Robert H.} and Lynn Tran and Alexandra King and Johnson, {Rodney W.} and Freund, {Gregory G.} and Robert Dantzer and Kelley, {Keith W.}",

year = "2007",

month = aug,

doi = "10.1016/j.jneuroim.2007.05.003",

language = "English (US)",

volume = "188",

pages = "48--55",

journal = "Advances in Neuroimmunology",

issn = "0165-5728",

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T2 - IL-10 prevents TNFα-induced resistance to IGF-I in myoblasts

AU - Strle, Klemen

AU - McCusker, Robert H.

AU - Tran, Lynn

AU - King, Alexandra

AU - Johnson, Rodney W.

AU - Freund, Gregory G.

AU - Dantzer, Robert

AU - Kelley, Keith W.

PY - 2007/8

Y1 - 2007/8

N2 - IL-10 is an anti-inflammatory cytokine that suppresses synthesis of proinflammatory cytokines and their receptors. Here we tested the possibility that TNFα-induced hormone resistance in myoblasts might be overcome by IL-10. We found that IL-10 restores myogenesis by suppressing the ability of exogenous TNFα to inhibit IGF-I-induced myogenin. This protection occurs without decreasing global activity of TNF receptors since IL-10 does not impair TNFα-induced IL-6 synthesis or ERK1/2 phosphorylation. Instead, IL-10 acts to prevent TNFα-induced phosphorylation of JNK. These findings demonstrate that IL-10 serves a previously unrecognized protective role in muscle progenitors by overcoming TNFα-induced resistance to IGF-I.

AB - IL-10 is an anti-inflammatory cytokine that suppresses synthesis of proinflammatory cytokines and their receptors. Here we tested the possibility that TNFα-induced hormone resistance in myoblasts might be overcome by IL-10. We found that IL-10 restores myogenesis by suppressing the ability of exogenous TNFα to inhibit IGF-I-induced myogenin. This protection occurs without decreasing global activity of TNF receptors since IL-10 does not impair TNFα-induced IL-6 synthesis or ERK1/2 phosphorylation. Instead, IL-10 acts to prevent TNFα-induced phosphorylation of JNK. These findings demonstrate that IL-10 serves a previously unrecognized protective role in muscle progenitors by overcoming TNFα-induced resistance to IGF-I.

KW - Cytokines

KW - Hormone resistance

KW - IGF-I

KW - Inflammation

KW - JNK

KW - Muscle

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JO - Advances in Neuroimmunology

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ER -

Novel activity of an anti-inflammatory cytokine: IL-10 prevents TNFα-induced resistance to IGF-I in myoblasts

Abstract

Keywords

ASJC Scopus subject areas

Online availability

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