TY - JOUR
T1 - Not your father’s planarian
T2 - A classic model enters the era of functional genomics
AU - Newmark, Phillip A.
AU - Alvarado, Alejandro Sánchez
PY - 2002
Y1 - 2002
N2 - Freshwater planarians were a classic model for studying the problems of development and regeneration. However, as attention shifted towards animals with more rigid developmental processes, the planarians, with their notoriously plastic ontogeny, declined in significance as a model system. This trend was exacerbated with the introduction of genetic and molecular approaches, which did not work well in planarians. More recently, the heightened interest in stem-cell biology, along with the successful application of molecular, cellular and genomic approaches in planarians, is re-establishing these fascinating organisms as models for studying regeneration and developmental plasticity.
AB - Freshwater planarians were a classic model for studying the problems of development and regeneration. However, as attention shifted towards animals with more rigid developmental processes, the planarians, with their notoriously plastic ontogeny, declined in significance as a model system. This trend was exacerbated with the introduction of genetic and molecular approaches, which did not work well in planarians. More recently, the heightened interest in stem-cell biology, along with the successful application of molecular, cellular and genomic approaches in planarians, is re-establishing these fascinating organisms as models for studying regeneration and developmental plasticity.
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U2 - 10.1038/nrg759
DO - 10.1038/nrg759
M3 - Review article
C2 - 11972158
AN - SCOPUS:0036255131
SN - 1471-0056
VL - 3
SP - 210
EP - 219
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
IS - 3
ER -