Nonreplication of an association of SGIP1 SNPs with alcohol dependence and resting theta EEG power

Jaime Derringer, Robert F. Krueger, Niklas Manz, Bernice Porjesz, Laura Almasy, Ebony Bookman, Howard J. Edenberg, John R. Kramer, Jay A. Tischfield, Laura J. Bierut

Research output: Contribution to journalArticlepeer-review


A recent study in a sample of Plains Indians showed association between eight single nucleotide polymorphisms (SNPs) located in the SGIP1 gene and resting θ electroencephalogram (EEG) power. This association appeared to generalize to alcohol use disorders, for which EEG power is a potential endophenotype. We analyzed a large, diverse sample for replication of the association of these implicated SGIP1 SNPs (genotyped on the Illumina 1M platform) with alcohol dependence (N=3988) and θ EEG power (N=1066). We found no evidence of association of the earlier implicated SGIP1 SNPs with either alcohol dependence or θ EEG power (all P>0.15) in this sample. The earlier implicated SNPs located in SGIP1 gene showed no association with alcohol dependence or θ EEG power in this sample of individuals with European and/or African ancestry. This failure to replicate may be the result of differences in ancestry between this sample and the original sample.

Original languageEnglish (US)
Pages (from-to)265-266
Number of pages2
JournalPsychiatric Genetics
Issue number5
StatePublished - Oct 2011
Externally publishedYes


  • alcoholism
  • candidate gene association study
  • electroencephalogram

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry


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