Nonreplication of an association of SGIP1 SNPs with alcohol dependence and resting theta EEG power

Jaime Derringer; Robert F. Krueger; Niklas Manz; Bernice Porjesz; Laura Almasy; Ebony Bookman; Howard J. Edenberg; John R. Kramer; Jay A. Tischfield; Laura J. Bierut

doi:10.1097/YPG.0b013e32834371fd

Nonreplication of an association of SGIP1 SNPs with alcohol dependence and resting theta EEG power

Jaime Derringer, Robert F. Krueger, Niklas Manz, Bernice Porjesz, Laura Almasy, Ebony Bookman, Howard J. Edenberg, John R. Kramer, Jay A. Tischfield, Laura J. Bierut

Research output: Contribution to journal › Article › peer-review

Abstract

A recent study in a sample of Plains Indians showed association between eight single nucleotide polymorphisms (SNPs) located in the SGIP1 gene and resting θ electroencephalogram (EEG) power. This association appeared to generalize to alcohol use disorders, for which EEG power is a potential endophenotype. We analyzed a large, diverse sample for replication of the association of these implicated SGIP1 SNPs (genotyped on the Illumina 1M platform) with alcohol dependence (N=3988) and θ EEG power (N=1066). We found no evidence of association of the earlier implicated SGIP1 SNPs with either alcohol dependence or θ EEG power (all P>0.15) in this sample. The earlier implicated SNPs located in SGIP1 gene showed no association with alcohol dependence or θ EEG power in this sample of individuals with European and/or African ancestry. This failure to replicate may be the result of differences in ancestry between this sample and the original sample.

Original language	English (US)
Pages (from-to)	265-266
Number of pages	2
Journal	Psychiatric Genetics
Volume	21
Issue number	5
DOIs	https://doi.org/10.1097/YPG.0b013e32834371fd
State	Published - Oct 2011
Externally published	Yes

Keywords

alcoholism
candidate gene association study
electroencephalogram

ASJC Scopus subject areas

Genetics
Genetics(clinical)
Psychiatry and Mental health
Biological Psychiatry

Online availability

10.1097/YPG.0b013e32834371fd

Library availability

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title = "Nonreplication of an association of SGIP1 SNPs with alcohol dependence and resting theta EEG power",

abstract = "A recent study in a sample of Plains Indians showed association between eight single nucleotide polymorphisms (SNPs) located in the SGIP1 gene and resting θ electroencephalogram (EEG) power. This association appeared to generalize to alcohol use disorders, for which EEG power is a potential endophenotype. We analyzed a large, diverse sample for replication of the association of these implicated SGIP1 SNPs (genotyped on the Illumina 1M platform) with alcohol dependence (N=3988) and θ EEG power (N=1066). We found no evidence of association of the earlier implicated SGIP1 SNPs with either alcohol dependence or θ EEG power (all P>0.15) in this sample. The earlier implicated SNPs located in SGIP1 gene showed no association with alcohol dependence or θ EEG power in this sample of individuals with European and/or African ancestry. This failure to replicate may be the result of differences in ancestry between this sample and the original sample.",

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AU - Derringer, Jaime

AU - Krueger, Robert F.

AU - Manz, Niklas

AU - Porjesz, Bernice

AU - Almasy, Laura

AU - Bookman, Ebony

AU - Edenberg, Howard J.

AU - Kramer, John R.

AU - Tischfield, Jay A.

AU - Bierut, Laura J.

PY - 2011/10

Y1 - 2011/10

N2 - A recent study in a sample of Plains Indians showed association between eight single nucleotide polymorphisms (SNPs) located in the SGIP1 gene and resting θ electroencephalogram (EEG) power. This association appeared to generalize to alcohol use disorders, for which EEG power is a potential endophenotype. We analyzed a large, diverse sample for replication of the association of these implicated SGIP1 SNPs (genotyped on the Illumina 1M platform) with alcohol dependence (N=3988) and θ EEG power (N=1066). We found no evidence of association of the earlier implicated SGIP1 SNPs with either alcohol dependence or θ EEG power (all P>0.15) in this sample. The earlier implicated SNPs located in SGIP1 gene showed no association with alcohol dependence or θ EEG power in this sample of individuals with European and/or African ancestry. This failure to replicate may be the result of differences in ancestry between this sample and the original sample.

AB - A recent study in a sample of Plains Indians showed association between eight single nucleotide polymorphisms (SNPs) located in the SGIP1 gene and resting θ electroencephalogram (EEG) power. This association appeared to generalize to alcohol use disorders, for which EEG power is a potential endophenotype. We analyzed a large, diverse sample for replication of the association of these implicated SGIP1 SNPs (genotyped on the Illumina 1M platform) with alcohol dependence (N=3988) and θ EEG power (N=1066). We found no evidence of association of the earlier implicated SGIP1 SNPs with either alcohol dependence or θ EEG power (all P>0.15) in this sample. The earlier implicated SNPs located in SGIP1 gene showed no association with alcohol dependence or θ EEG power in this sample of individuals with European and/or African ancestry. This failure to replicate may be the result of differences in ancestry between this sample and the original sample.

KW - alcoholism

KW - candidate gene association study

KW - electroencephalogram

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Nonreplication of an association of SGIP1 SNPs with alcohol dependence and resting theta EEG power

Abstract

Keywords

ASJC Scopus subject areas

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