Abstract

We demonstrate imaging with the technique of nonlinear interferometric vibrational imaging (NIVI). Experimental images using this instrumentation and method have been acquired from both phantom and biological tissues. In our system, coherent anti-Stokes Raman scattering (CARS) signals are detected by spectral interferometry, which is able to fully restore high resolution Raman spectrum on each focal spot of a sample covering multiple Raman bands using broadband pump and Stokes laser beams. Spectral-domain detection has been demonstrated and allows for a significant increase in image acquiring speed, in signal-to-noise, and in interferometric signal stability.

Original languageEnglish (US)
Title of host publicationMultiphoton Microscopy in the Biomedical Sciences VIII
DOIs
StatePublished - Apr 21 2008
EventMultiphoton Microscopy in the Biomedical Sciences VIII - San Jose, CA, United States
Duration: Jan 20 2008Jan 22 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6860
ISSN (Print)1605-7422

Other

OtherMultiphoton Microscopy in the Biomedical Sciences VIII
CountryUnited States
CitySan Jose, CA
Period1/20/081/22/08

Fingerprint

Raman scattering
Tissue
Imaging techniques
Interferometry
Laser beams
Pumps

Keywords

  • Biomedical imaging
  • Coherent anti-Stokes Raman scattering
  • Nonlinear microscopy

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Jiang, Z., Marks, D. L., Geddes, J. B., & Boppart, S. A. (2008). Nonlinear interferometric vibrational imaging of biological tissue. In Multiphoton Microscopy in the Biomedical Sciences VIII [68600Y] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6860). https://doi.org/10.1117/12.763306

Nonlinear interferometric vibrational imaging of biological tissue. / Jiang, Zhi; Marks, Daniel L.; Geddes, Joseph B.; Boppart, Stephen A.

Multiphoton Microscopy in the Biomedical Sciences VIII. 2008. 68600Y (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6860).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Jiang, Z, Marks, DL, Geddes, JB & Boppart, SA 2008, Nonlinear interferometric vibrational imaging of biological tissue. in Multiphoton Microscopy in the Biomedical Sciences VIII., 68600Y, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 6860, Multiphoton Microscopy in the Biomedical Sciences VIII, San Jose, CA, United States, 1/20/08. https://doi.org/10.1117/12.763306
Jiang Z, Marks DL, Geddes JB, Boppart SA. Nonlinear interferometric vibrational imaging of biological tissue. In Multiphoton Microscopy in the Biomedical Sciences VIII. 2008. 68600Y. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.763306
Jiang, Zhi ; Marks, Daniel L. ; Geddes, Joseph B. ; Boppart, Stephen A. / Nonlinear interferometric vibrational imaging of biological tissue. Multiphoton Microscopy in the Biomedical Sciences VIII. 2008. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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