We demonstrate imaging with the technique of nonlinear interferometric vibrational imaging (NIVI). Experimental images using this instrumentation and method have been acquired from both phantom and biological tissues. In our system, coherent anti-Stokes Raman scattering (CARS) signals are detected by spectral interferometry, which is able to fully restore high resolution Raman spectrum on each focal spot of a sample covering multiple Raman bands using broadband pump and Stokes laser beams. Spectral-domain detection has been demonstrated and allows for a significant increase in image acquiring speed, in signal-to-noise, and in interferometric signal stability.

Original languageEnglish (US)
Title of host publicationMultiphoton Microscopy in the Biomedical Sciences VIII
StatePublished - 2008
EventMultiphoton Microscopy in the Biomedical Sciences VIII - San Jose, CA, United States
Duration: Jan 20 2008Jan 22 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMultiphoton Microscopy in the Biomedical Sciences VIII
Country/TerritoryUnited States
CitySan Jose, CA


  • Biomedical imaging
  • Coherent anti-Stokes Raman scattering
  • Nonlinear microscopy

ASJC Scopus subject areas

  • General Engineering


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