Abstract

Optical imaging is essential in medicine and in fundamental studies of biological systems. Although many existing imaging modalities can supply valuable information, not all are capable of label–free imaging with high–contrast and molecular specificity. The application of molecular or nanoparticle contrast agents may adversely influence the biological system under investigation. These substances also present ongoing concerns over toxicity or particle clearance, which must be properly addressed before their approval for in vivo human imaging. Hence there is an increasing appreciation for label–free imaging techniques. It is of primary importance to develop imaging techniques that can indiscriminately identify and quantify biochemical compositions to high degrees of sensitivity and specificity through only the intrinsic optical response of endogenous molecular species. The development and use of nonlinear interferometric vibrational imaging, which is based on the interferometric detection of optical signals from coherent anti–Stokes Raman scattering (CARS), along with novel optical sources, offers the potential for label–free molecular imaging.

Original languageEnglish (US)
Title of host publicationOptical Coherence Tomography
Subtitle of host publicationTechnology and Applications, Second Edition
PublisherSpringer International Publishing
Pages1237-1256
Number of pages20
ISBN (Electronic)9783319064192
ISBN (Print)9783319064185
DOIs
StatePublished - Jan 1 2015

Fingerprint

Molecular Imaging
Raman Spectrum Analysis
Optical Imaging
imaging techniques
Nanoparticles
Contrast Media
Light sources
Medicine
Imaging techniques
Sensitivity and Specificity
coherent scattering
clearances
medicine
toxicity
optical communication
Raman spectra
nanoparticles
Biological systems
sensitivity
Coherent scattering

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)

Cite this

Boppart, S. A., King, M. D., Liu, Y., Tu, H., & Gruebele, M. (2015). Nonlinear interferometric vibrational imaging (NIVI) with novel optical sources. In Optical Coherence Tomography: Technology and Applications, Second Edition (pp. 1237-1256). Springer International Publishing. https://doi.org/10.1007/978-3-319-06419-2_39

Nonlinear interferometric vibrational imaging (NIVI) with novel optical sources. / Boppart, Stephen A.; King, Matthew D.; Liu, Yuan; Tu, Haohua; Gruebele, Martin.

Optical Coherence Tomography: Technology and Applications, Second Edition. Springer International Publishing, 2015. p. 1237-1256.

Research output: Chapter in Book/Report/Conference proceedingChapter

Boppart, SA, King, MD, Liu, Y, Tu, H & Gruebele, M 2015, Nonlinear interferometric vibrational imaging (NIVI) with novel optical sources. in Optical Coherence Tomography: Technology and Applications, Second Edition. Springer International Publishing, pp. 1237-1256. https://doi.org/10.1007/978-3-319-06419-2_39
Boppart SA, King MD, Liu Y, Tu H, Gruebele M. Nonlinear interferometric vibrational imaging (NIVI) with novel optical sources. In Optical Coherence Tomography: Technology and Applications, Second Edition. Springer International Publishing. 2015. p. 1237-1256 https://doi.org/10.1007/978-3-319-06419-2_39
Boppart, Stephen A. ; King, Matthew D. ; Liu, Yuan ; Tu, Haohua ; Gruebele, Martin. / Nonlinear interferometric vibrational imaging (NIVI) with novel optical sources. Optical Coherence Tomography: Technology and Applications, Second Edition. Springer International Publishing, 2015. pp. 1237-1256
@inbook{d3fe2f9f03e34c99b85812f9c454c24f,
title = "Nonlinear interferometric vibrational imaging (NIVI) with novel optical sources",
abstract = "Optical imaging is essential in medicine and in fundamental studies of biological systems. Although many existing imaging modalities can supply valuable information, not all are capable of label–free imaging with high–contrast and molecular specificity. The application of molecular or nanoparticle contrast agents may adversely influence the biological system under investigation. These substances also present ongoing concerns over toxicity or particle clearance, which must be properly addressed before their approval for in vivo human imaging. Hence there is an increasing appreciation for label–free imaging techniques. It is of primary importance to develop imaging techniques that can indiscriminately identify and quantify biochemical compositions to high degrees of sensitivity and specificity through only the intrinsic optical response of endogenous molecular species. The development and use of nonlinear interferometric vibrational imaging, which is based on the interferometric detection of optical signals from coherent anti–Stokes Raman scattering (CARS), along with novel optical sources, offers the potential for label–free molecular imaging.",
author = "Boppart, {Stephen A.} and King, {Matthew D.} and Yuan Liu and Haohua Tu and Martin Gruebele",
year = "2015",
month = "1",
day = "1",
doi = "10.1007/978-3-319-06419-2_39",
language = "English (US)",
isbn = "9783319064185",
pages = "1237--1256",
booktitle = "Optical Coherence Tomography",
publisher = "Springer International Publishing",

}

TY - CHAP

T1 - Nonlinear interferometric vibrational imaging (NIVI) with novel optical sources

AU - Boppart, Stephen A.

AU - King, Matthew D.

AU - Liu, Yuan

AU - Tu, Haohua

AU - Gruebele, Martin

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Optical imaging is essential in medicine and in fundamental studies of biological systems. Although many existing imaging modalities can supply valuable information, not all are capable of label–free imaging with high–contrast and molecular specificity. The application of molecular or nanoparticle contrast agents may adversely influence the biological system under investigation. These substances also present ongoing concerns over toxicity or particle clearance, which must be properly addressed before their approval for in vivo human imaging. Hence there is an increasing appreciation for label–free imaging techniques. It is of primary importance to develop imaging techniques that can indiscriminately identify and quantify biochemical compositions to high degrees of sensitivity and specificity through only the intrinsic optical response of endogenous molecular species. The development and use of nonlinear interferometric vibrational imaging, which is based on the interferometric detection of optical signals from coherent anti–Stokes Raman scattering (CARS), along with novel optical sources, offers the potential for label–free molecular imaging.

AB - Optical imaging is essential in medicine and in fundamental studies of biological systems. Although many existing imaging modalities can supply valuable information, not all are capable of label–free imaging with high–contrast and molecular specificity. The application of molecular or nanoparticle contrast agents may adversely influence the biological system under investigation. These substances also present ongoing concerns over toxicity or particle clearance, which must be properly addressed before their approval for in vivo human imaging. Hence there is an increasing appreciation for label–free imaging techniques. It is of primary importance to develop imaging techniques that can indiscriminately identify and quantify biochemical compositions to high degrees of sensitivity and specificity through only the intrinsic optical response of endogenous molecular species. The development and use of nonlinear interferometric vibrational imaging, which is based on the interferometric detection of optical signals from coherent anti–Stokes Raman scattering (CARS), along with novel optical sources, offers the potential for label–free molecular imaging.

UR - http://www.scopus.com/inward/record.url?scp=84945139644&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84945139644&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-06419-2_39

DO - 10.1007/978-3-319-06419-2_39

M3 - Chapter

AN - SCOPUS:84945139644

SN - 9783319064185

SP - 1237

EP - 1256

BT - Optical Coherence Tomography

PB - Springer International Publishing

ER -