Non-viral gene delivery via membrane-penetrating, mannose-targeting supramolecular self-assembled nanocomplexes

Lichen Yin; Ziyuan Song; Kyung Hoon Kim; Nan Zheng; Nathan P. Gabrielson; Jianjun Cheng

doi:10.1002/adma.201205088

Non-viral gene delivery via membrane-penetrating, mannose-targeting supramolecular self-assembled nanocomplexes

Lichen Yin, Ziyuan Song, Kyung Hoon Kim, Nan Zheng, Nathan P. Gabrielson, Jianjun Cheng

Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

Supramolecular self-assembled nanocomplexes (SSANs) capable of mannose receptor-mediated endocytosis and permeable to cellular and endosomal membranes are developed via the assembly of multiple rationally designed, function-specific materials. As a unique non-viral gene delivery vector, SSANs outperform commercial transfection reagents, including LPF2000, PEI, and jetPEI, by up to 2 orders of magnitude.

Original language	English (US)
Pages (from-to)	3063-3070
Number of pages	8
Journal	Advanced Materials
Volume	25
Issue number	22
DOIs	https://doi.org/10.1002/adma.201205088
State	Published - Jun 11 2013

Keywords

cell penetrating peptides
mannose targeting
non-viral gene delivery
supramolecular self-assembly

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.201205088

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abstract = "Supramolecular self-assembled nanocomplexes (SSANs) capable of mannose receptor-mediated endocytosis and permeable to cellular and endosomal membranes are developed via the assembly of multiple rationally designed, function-specific materials. As a unique non-viral gene delivery vector, SSANs outperform commercial transfection reagents, including LPF2000, PEI, and jetPEI, by up to 2 orders of magnitude.",

keywords = "cell penetrating peptides, mannose targeting, non-viral gene delivery, supramolecular self-assembly",

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language = "English (US)",

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AU - Yin, Lichen

AU - Song, Ziyuan

AU - Kim, Kyung Hoon

AU - Zheng, Nan

AU - Gabrielson, Nathan P.

AU - Cheng, Jianjun

PY - 2013/6/11

Y1 - 2013/6/11

N2 - Supramolecular self-assembled nanocomplexes (SSANs) capable of mannose receptor-mediated endocytosis and permeable to cellular and endosomal membranes are developed via the assembly of multiple rationally designed, function-specific materials. As a unique non-viral gene delivery vector, SSANs outperform commercial transfection reagents, including LPF2000, PEI, and jetPEI, by up to 2 orders of magnitude.

AB - Supramolecular self-assembled nanocomplexes (SSANs) capable of mannose receptor-mediated endocytosis and permeable to cellular and endosomal membranes are developed via the assembly of multiple rationally designed, function-specific materials. As a unique non-viral gene delivery vector, SSANs outperform commercial transfection reagents, including LPF2000, PEI, and jetPEI, by up to 2 orders of magnitude.

KW - cell penetrating peptides

KW - mannose targeting

KW - non-viral gene delivery

KW - supramolecular self-assembly

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Non-viral gene delivery via membrane-penetrating, mannose-targeting supramolecular self-assembled nanocomplexes

Abstract

Keywords

ASJC Scopus subject areas

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