@inbook{a2cc45cacd4048078b9e6055e9186f5d,
title = "Non-targeted identification of d-amino acid-containing peptides through enzymatic screening, chiral amino acid analysis, and LC-MS",
abstract = "d-Amino acid-containing peptides (DAACPs) in animals are a class of bioactive molecules formed via the posttranslational modification of peptides consisting of all-l-amino acid residues. Amino acid residue isomerization greatly impacts the function of the resulting DAACP. However, because isomerization does not change the peptide{\textquoteright}s mass, this modification is difficult to detect by most mass spectrometry-based peptidomic approaches. Here we describe a method for the identification of DAACPs that can be used to systematically survey peptides extracted from a tissue sample in a non-targeted manner.",
keywords = "Bioactive peptides, Chirality, Peptide isomerization, Posttranslational modifications, d-Amino acid-containing peptides",
author = "Tai, {Hua Chia} and Checco, {James W.} and Sweedler, {Jonathan V.}",
note = "Publisher Copyright: {\textcopyright} 2018, Springer Science+Business Media, LLC.",
year = "2018",
doi = "10.1007/978-1-4939-7537-2_7",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "107--118",
booktitle = "Methods in Molecular Biology",
}