TY - JOUR
T1 - Non-spherical particles for targeted drug delivery
AU - Chen, Jinrong
AU - Clay, Nicholas E.
AU - Park, No hyung
AU - Kong, Hyunjoon
N1 - Funding Information:
This work was supported by the National Institutes of Health ( 1R01 HL109192 to H.J.K. and R25 CA154015A to J.C.) and the Center for Advanced Study at the University of Illinois . We would also like to acknowledge the Korean Institute of Industrial Technology for additional support.
Publisher Copyright:
© 2014 Elsevier Ltd.
PY - 2015/3/4
Y1 - 2015/3/4
N2 - Nano- and microparticles loaded with various bioimaging contrast agents or therapeutic molecules have been increasingly used for the diagnosis and treatment of diseases and tissue defects. These particles, often a filled or hollow sphere, can extend the lifetime of encapsulated biomedical modalities in circulation and in target tissue. However, there is a great need to improve the drug loading and targeting efficiency of these particles. Recently, several simulations and in vitro experimental studies reported that particle shape plays a pivotal role in the targeted delivery of molecules. To better understand these findings and subsequently expedite the use of particles in biomedical applications, this review paper summarizes the methods to prepare non-spherical nano- and micro-scaled particles. In addition, this review covers studies reporting the effects of particle shape on the loading, delivery, and release of encapsulated bioactive cargos. Finally, it discusses future directions to further improve the properties of non-spherical particles.
AB - Nano- and microparticles loaded with various bioimaging contrast agents or therapeutic molecules have been increasingly used for the diagnosis and treatment of diseases and tissue defects. These particles, often a filled or hollow sphere, can extend the lifetime of encapsulated biomedical modalities in circulation and in target tissue. However, there is a great need to improve the drug loading and targeting efficiency of these particles. Recently, several simulations and in vitro experimental studies reported that particle shape plays a pivotal role in the targeted delivery of molecules. To better understand these findings and subsequently expedite the use of particles in biomedical applications, this review paper summarizes the methods to prepare non-spherical nano- and micro-scaled particles. In addition, this review covers studies reporting the effects of particle shape on the loading, delivery, and release of encapsulated bioactive cargos. Finally, it discusses future directions to further improve the properties of non-spherical particles.
KW - Drug loading
KW - Non-spherical particles
KW - Particle fabrication
KW - Release rate
KW - Targeting efficiency
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U2 - 10.1016/j.ces.2014.10.022
DO - 10.1016/j.ces.2014.10.022
M3 - Article
AN - SCOPUS:85027916771
SN - 0009-2509
VL - 125
SP - 20
EP - 24
JO - Chemical Engineering Science
JF - Chemical Engineering Science
ER -