Non-ribosomal incorporation of arginine into a specific protein by a cell-free extract of parathyroid tissue

Byron Kemper, Joel F. Habener

Research output: Contribution to journalArticle

Abstract

Both cell-free extracts and postribosomal supernatants of bovine parathyroid glands incorporated [14C] arginine from a mixture of 14C-labeled amino acids into protein and specifically into a protein with electrophoretic properties similar to those of parathyroid hormone. A single-step Edman degradation removed 75% of the [14C] arginine from radioactive proteins. These observations indicate that parathyroid tissue contains a soluble enzyme that catalyzes the incorporation of arginine into the amino terminus of parathyroid proteins including either parathyroid hormone or a closely related protein.

Original languageEnglish (US)
Pages (from-to)235-239
Number of pages5
JournalBBA Section Nucleic Acids And Protein Synthesis
Volume349
Issue number2
DOIs
StatePublished - May 17 1974
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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