Non-invasive in-vivo temperature mapping of ultrasound heating using fluorine-based magnetic resonance imaging agents

Andrew G. Webb; Nadine Barrie Smith; D. Scott Ellis; William D. O'Brien

Non-invasive in-vivo temperature mapping of ultrasound heating using fluorine-based magnetic resonance imaging agents

Andrew G. Webb
, Nadine Barrie Smith
, D. Scott Ellis
, William D. O'Brien

Research output: Contribution to journal › Conference article › peer-review

Abstract

The aim of this study was to investigate the feasibility of using fluorine based magnetic resonance to measure accurately hepatic heating from a focused ultrasound transducer in rats. This new method uses the temperature dependence of the difference in fluorine chemical shifts within a single molecule to provide internal compensation for complicating physiological effects. Female Sprague-Dawley rats were exposed to 5 minutes of CW irradiation at 1.37 MHz from a focused transducer. Theoretical calculations based on the monopole source solution to the bio-heat transfer equation gave a volume-averaged temperature rise of 2.1°C. Preliminary experiments using protein encapsulated perfluorooctylbromide targeted to the liver gave an empirical rise of 2.0 ±0.4°C.

Original language	English (US)
Pages (from-to)	1609-1612
Number of pages	4
Journal	Proceedings of the IEEE Ultrasonics Symposium
Volume	2
State	Published - 1995
Event	Proceedings of the 1995 IEEE Ultrasonics Symposium. Part 1 (of 2) - Seattle, WA, USA Duration: Nov 7 1995 → Nov 10 1995

ASJC Scopus subject areas

Acoustics and Ultrasonics

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@article{6217945970914db292fd13cb431c3c0e,

title = "Non-invasive in-vivo temperature mapping of ultrasound heating using fluorine-based magnetic resonance imaging agents",

abstract = "The aim of this study was to investigate the feasibility of using fluorine based magnetic resonance to measure accurately hepatic heating from a focused ultrasound transducer in rats. This new method uses the temperature dependence of the difference in fluorine chemical shifts within a single molecule to provide internal compensation for complicating physiological effects. Female Sprague-Dawley rats were exposed to 5 minutes of CW irradiation at 1.37 MHz from a focused transducer. Theoretical calculations based on the monopole source solution to the bio-heat transfer equation gave a volume-averaged temperature rise of 2.1°C. Preliminary experiments using protein encapsulated perfluorooctylbromide targeted to the liver gave an empirical rise of 2.0 ±0.4°C.",

author = "Webb, \{Andrew G.\} and \{Barrie Smith\}, Nadine and \{Scott Ellis\}, D. and O'Brien, \{William D.\}",

year = "1995",

language = "English (US)",

volume = "2",

pages = "1609--1612",

journal = "Proceedings of the IEEE Ultrasonics Symposium",

issn = "1051-0117",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

note = "Proceedings of the 1995 IEEE Ultrasonics Symposium. Part 1 (of 2) ; Conference date: 07-11-1995 Through 10-11-1995",

}

TY - JOUR

T1 - Non-invasive in-vivo temperature mapping of ultrasound heating using fluorine-based magnetic resonance imaging agents

AU - Webb, Andrew G.

AU - Barrie Smith, Nadine

AU - Scott Ellis, D.

AU - O'Brien, William D.

PY - 1995

Y1 - 1995

N2 - The aim of this study was to investigate the feasibility of using fluorine based magnetic resonance to measure accurately hepatic heating from a focused ultrasound transducer in rats. This new method uses the temperature dependence of the difference in fluorine chemical shifts within a single molecule to provide internal compensation for complicating physiological effects. Female Sprague-Dawley rats were exposed to 5 minutes of CW irradiation at 1.37 MHz from a focused transducer. Theoretical calculations based on the monopole source solution to the bio-heat transfer equation gave a volume-averaged temperature rise of 2.1°C. Preliminary experiments using protein encapsulated perfluorooctylbromide targeted to the liver gave an empirical rise of 2.0 ±0.4°C.

AB - The aim of this study was to investigate the feasibility of using fluorine based magnetic resonance to measure accurately hepatic heating from a focused ultrasound transducer in rats. This new method uses the temperature dependence of the difference in fluorine chemical shifts within a single molecule to provide internal compensation for complicating physiological effects. Female Sprague-Dawley rats were exposed to 5 minutes of CW irradiation at 1.37 MHz from a focused transducer. Theoretical calculations based on the monopole source solution to the bio-heat transfer equation gave a volume-averaged temperature rise of 2.1°C. Preliminary experiments using protein encapsulated perfluorooctylbromide targeted to the liver gave an empirical rise of 2.0 ±0.4°C.

UR - https://www.scopus.com/pages/publications/0029463529

UR - https://www.scopus.com/pages/publications/0029463529#tab=citedBy

M3 - Conference article

AN - SCOPUS:0029463529

SN - 1051-0117

VL - 2

SP - 1609

EP - 1612

JO - Proceedings of the IEEE Ultrasonics Symposium

JF - Proceedings of the IEEE Ultrasonics Symposium

T2 - Proceedings of the 1995 IEEE Ultrasonics Symposium. Part 1 (of 2)

Y2 - 7 November 1995 through 10 November 1995

ER -

Non-invasive in-vivo temperature mapping of ultrasound heating using fluorine-based magnetic resonance imaging agents

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