Abstract
The aim of this study was to investigate the feasibility of using fluorine based magnetic resonance to measure accurately hepatic heating from a focused ultrasound transducer in rats. This new method uses the temperature dependence of the difference in fluorine chemical shifts within a single molecule to provide internal compensation for complicating physiological effects. Female Sprague-Dawley rats were exposed to 5 minutes of CW irradiation at 1.37 MHz from a focused transducer. Theoretical calculations based on the monopole source solution to the bio-heat transfer equation gave a volume-averaged temperature rise of 2.1°C. Preliminary experiments using protein encapsulated perfluorooctylbromide targeted to the liver gave an empirical rise of 2.0 ±0.4°C.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1609-1612 |
| Number of pages | 4 |
| Journal | Proceedings of the IEEE Ultrasonics Symposium |
| Volume | 2 |
| State | Published - 1995 |
| Event | Proceedings of the 1995 IEEE Ultrasonics Symposium. Part 1 (of 2) - Seattle, WA, USA Duration: Nov 7 1995 → Nov 10 1995 |
ASJC Scopus subject areas
- Acoustics and Ultrasonics