TY - JOUR
T1 - No Associations Between Physical Activity and Immunogenicity in SARS-CoV-2 Seropositive Patients With Autoimmune Rheumatic Diseases Prior to and After Vaccination
AU - Smaira, Fabiana Infante
AU - Mazzolani, Bruna Caruso
AU - Lemes, Ítalo Ribeiro
AU - da Silva, Rafael Pires
AU - Pinto, Ana J.
AU - Sieczkowska, Sofia M.
AU - Aikawa, Nadia E.
AU - Pasoto, Sandra G.
AU - Medeiros-Ribeiro, Ana C.
AU - Saad, Carla G.S.
AU - Yuk, Emily F.N.
AU - Silva, Clovis A.
AU - Swinton, Paul
AU - de Vinci Kanda Kupa, Leonard
AU - Hallal, Pedro C.
AU - Roschel, Hamilton
AU - Gualano, Bruno
AU - Bonfa, Eloisa
N1 - Publisher Copyright:
© 2023 Human Kinetics, Inc.
PY - 2023
Y1 - 2023
N2 - Aim: To investigate the association between physical activity and immunogenicity among SARS-CoV-2 seropositive patients with autoimmune rheumatic diseases prior to and following a 2-dose schedule of CoronaVac (Sinovac inactivated vaccine). Methods: This was a prospective cohort study within an open-label, single-arm, phase 4 vaccination trial conducted in Sao Paulo, Brazil. In this substudy, only SARS-CoV-2 seropositive patients were included. Immunogenicity was assessed by seroconversion rates of total anti-SARS-CoV-2 S1/S2 immunoglobulin G (IgG), geometric mean titers of anti-S1/S2 IgG, frequency of positive neutralizing antibodies, and neutralizing activity before and after vaccination. Physical activity was assessed through a questionnaire. Model-based analyses were performed controlling for age (<60 or ≥60 y), sex, body mass index (<25, 25–30, and >30 kg/m2), and use of prednisone, immunosuppressants, and biologics. Results: A total of 180 seropositive autoimmune rheumatic disease patients were included. There was no association between physical activity and immunogenicity before and after vaccination. Conclusions: This study suggests that the positive association between physical activity and greater antibody responses seen in immunocompromised individuals following vaccination is overridden by previous SARS-CoV-2 infection, and does not extend to natural immunity.
AB - Aim: To investigate the association between physical activity and immunogenicity among SARS-CoV-2 seropositive patients with autoimmune rheumatic diseases prior to and following a 2-dose schedule of CoronaVac (Sinovac inactivated vaccine). Methods: This was a prospective cohort study within an open-label, single-arm, phase 4 vaccination trial conducted in Sao Paulo, Brazil. In this substudy, only SARS-CoV-2 seropositive patients were included. Immunogenicity was assessed by seroconversion rates of total anti-SARS-CoV-2 S1/S2 immunoglobulin G (IgG), geometric mean titers of anti-S1/S2 IgG, frequency of positive neutralizing antibodies, and neutralizing activity before and after vaccination. Physical activity was assessed through a questionnaire. Model-based analyses were performed controlling for age (<60 or ≥60 y), sex, body mass index (<25, 25–30, and >30 kg/m2), and use of prednisone, immunosuppressants, and biologics. Results: A total of 180 seropositive autoimmune rheumatic disease patients were included. There was no association between physical activity and immunogenicity before and after vaccination. Conclusions: This study suggests that the positive association between physical activity and greater antibody responses seen in immunocompromised individuals following vaccination is overridden by previous SARS-CoV-2 infection, and does not extend to natural immunity.
KW - COVID-19
KW - immunosuppression
KW - physical inactivity
KW - vaccine
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U2 - 10.1123/jpah.2022-0362
DO - 10.1123/jpah.2022-0362
M3 - Article
C2 - 37290768
AN - SCOPUS:85171901302
SN - 1543-3080
VL - 20
SP - 980
EP - 983
JO - Journal of Physical Activity and Health
JF - Journal of Physical Activity and Health
IS - 10
ER -