@article{1b8b84ed9bf748489e68954510b593a9,
title = "NIEHS/FDA CLARITY-BPA research program update",
abstract = "Bisphenol A (BPA) is a chemical used in the production of numerous consumer products resulting in potential daily human exposure to this chemical. The FDA previously evaluated the body of BPA toxicology data and determined that BPA is safe at current exposure levels. Although consistent with the assessment of some other regulatory agencies around the world, this determination of BPA safety continues to be debated in scientific and popular publications, resulting in conflicting messages to the public. Thus, the National Toxicology Program (NTP), National Institute of Environmental Health Sciences (NIEHS), and U.S. Food and Drug Administration (FDA) developed a consortium-based research program to link more effectively a variety of hypothesis-based research investigations and guideline-compliant safety testing with BPA. This collaboration is known as the Consortium Linking Academic and Regulatory Insights on BPA Toxicity (CLARITY-BPA). This paper provides a detailed description of the conduct of the study and a midterm update on progress of the CLARITY-BPA research program.",
keywords = "Bisphenol A, CLARITY-BPA, Consortium, Endocrine disruptors, FDA, NIEHS, NTP",
author = "Heindel, {Jerrold J.} and Newbold, {Retha R.} and Bucher, {John R.} and Lu{\'i}sa Camacho and Delclos, {K. Barry} and Lewis, {Sherry M.} and Michelle Vanlandingham and Churchwell, {Mona I.} and Twaddle, {Nathan C.} and Michelle McLellen and Mani Chidambaram and Matthew Bryant and Kellie Woodling and Costa, {Gon{\c c}alo Gamboa da} and Ferguson, {Sherry A.} and Jodi Flaws and Howard, {Paul C.} and Walker, {Nigel J.} and Zoeller, {R. Thomas} and Jennifer Fostel and Carolyn Favaro and Schug, {Thaddeus T.}",
note = "Funding Information: The NCTR portion of the study was conducted under the auspices of the National Toxicology Program and funded by an Interagency agreement (IAG) between the Food and Drug Administration and the National Institute of Environmental Health Sciences / National Institutes of Health (FDA IAG: 224-12-0003 ; NIEHS IAG: AES12013 ). We are grateful for the extraordinary efforts of the NCTR Animal Care, Diet Preparation, Information Technology, Microbiology, Pathology, Quality Assurance, and Veterinary Services staffs, the NTP Statistical Support Team of the Division of Bioinformatics and Biostatistics, as well as Ms. Kathy Carroll of the Office of Scientific Coordination, in the planning and conduct of this study. This manuscript was reviewed in accordance with USFDA and NIEHS procedures prior to submission. The opinions expressed in this paper do not necessarily reflect those of the USFDA. Publisher Copyright: {\textcopyright} 2015 Published by Elsevier Inc.",
year = "2015",
month = dec,
day = "1",
doi = "10.1016/j.reprotox.2015.07.075",
language = "English (US)",
volume = "58",
pages = "33--44",
journal = "Reproductigve Toxicoloy",
issn = "0890-6238",
publisher = "Elsevier Inc.",
}