Nickel-Catalyzed Dearomative trans -1,2-Carboamination

Lucas W. Hernandez, Ulrich Klöckner, Jola Pospech, Lilian Hauss, David Sarlah

Research output: Contribution to journalArticlepeer-review

Abstract

We describe the development of an arenophile-mediated, nickel-catalyzed dearomative trans-1,2-carboamination protocol. A range of readily available aromatic compounds was converted to the corresponding dienes using Grignard reagents as nucleophiles. This strategy provided products with exclusive trans-selectivity and high enantioselectivity was observed in case of benzene and naphthalene. The utility of this methodology was showcased by controlled and stereoselective preparation of small, functionalized molecules.

Original languageEnglish (US)
Pages (from-to)4503-4507
Number of pages5
JournalJournal of the American Chemical Society
Volume140
Issue number13
DOIs
StatePublished - Apr 4 2018

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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