Nick-based data storage in native nucleic acids

Olgica Milenkovic; Alvaro Gonzalo Hernandez; Huimin Zhao; Seyedkasra Tabatabaei

Nick-based data storage in native nucleic acids

Olgica Milenkovic (Inventor), Alvaro Gonzalo Hernandez (Inventor), Huimin Zhao (Inventor), Seyedkasra Tabatabaei (Inventor)

Research output: Patent

Abstract

Nick-based methods, devices, and systems for nick-based data storage in a deoxyribonucleic acid (DNA) sequence are disclosed. Digital information is encoded in a register of at least one copy of a double-stranded DNA sequence having a plurality of nickable positions. The data is translated into a sequence of values from a nick alphabet that is subsequently mapped to the plurality of nickable positions, and the DNA sequence is nicked according to the mapped values. Because the digital information is encoded as a series of nicked and non-nicked positions of a double-stranded DNA sequence, the nucleotide sequence of the DNA can be non-synthetic, or “native” DNA.

Original language	English (US)
U.S. patent number	11538554
Filing date	9/19/18
State	Published - Dec 27 2022

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title = "Nick-based data storage in native nucleic acids",

abstract = "Nick-based methods, devices, and systems for nick-based data storage in a deoxyribonucleic acid (DNA) sequence are disclosed. Digital information is encoded in a register of at least one copy of a double-stranded DNA sequence having a plurality of nickable positions. The data is translated into a sequence of values from a nick alphabet that is subsequently mapped to the plurality of nickable positions, and the DNA sequence is nicked according to the mapped values. Because the digital information is encoded as a series of nicked and non-nicked positions of a double-stranded DNA sequence, the nucleotide sequence of the DNA can be non-synthetic, or “native” DNA.",

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T1 - Nick-based data storage in native nucleic acids

AU - Milenkovic, Olgica

AU - Hernandez, Alvaro Gonzalo

AU - Zhao, Huimin

AU - Tabatabaei, Seyedkasra

PY - 2022/12/27

Y1 - 2022/12/27

N2 - Nick-based methods, devices, and systems for nick-based data storage in a deoxyribonucleic acid (DNA) sequence are disclosed. Digital information is encoded in a register of at least one copy of a double-stranded DNA sequence having a plurality of nickable positions. The data is translated into a sequence of values from a nick alphabet that is subsequently mapped to the plurality of nickable positions, and the DNA sequence is nicked according to the mapped values. Because the digital information is encoded as a series of nicked and non-nicked positions of a double-stranded DNA sequence, the nucleotide sequence of the DNA can be non-synthetic, or “native” DNA.

AB - Nick-based methods, devices, and systems for nick-based data storage in a deoxyribonucleic acid (DNA) sequence are disclosed. Digital information is encoded in a register of at least one copy of a double-stranded DNA sequence having a plurality of nickable positions. The data is translated into a sequence of values from a nick alphabet that is subsequently mapped to the plurality of nickable positions, and the DNA sequence is nicked according to the mapped values. Because the digital information is encoded as a series of nicked and non-nicked positions of a double-stranded DNA sequence, the nucleotide sequence of the DNA can be non-synthetic, or “native” DNA.

M3 - Patent

M1 - 11538554

Y2 - 2018/09/19

ER -

Nick-based data storage in native nucleic acids

Abstract

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