Abstract

This review describes several state of the art advances made in the field of cancer nanotechnology that bring the science closer to clinical realization for application in disease treatment and diagnosis. For therapeutic delivery, in vivo strategies to improve the biodistribution, tumor penetration, and cellular uptake of nanocarriers are discussed, including the precise control of formulation and conjugation of targeting agents. We highlight recently developed novel nanosolutions that specifically address cancer metastasis. We also describe in detail the promising use of nanotechnologies for in vitro diagnostics on tissue section samples, an area that appears to be ready for clinical application in the near future. Finally, we discuss emerging discoveries on the unique biophysical properties of cancer that hold promise for paradigm shifts in future cancer diagnosis and treatment strategies as this field continues to mature.

Original languageEnglish (US)
Pages (from-to)144-151
Number of pages8
JournalCancer and Chemotherapy Reviews
Volume3
Issue number3
StatePublished - Dec 1 2008

Keywords

  • Cancer targeting
  • Cell mechanics
  • Drug delivery
  • Multiplex spectral imaging
  • Nanocarriers
  • Nanotechnology
  • Raman spectroscopy

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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