New wine from old barrels

Research output: Contribution to journalShort surveypeer-review


Phosphoribosylanthranilate isomerase (PRAI) and indole-3-glycerol phosphate synthase (IGPS) are distantly related α/β-barrel enzymes that catalyze successive steps in tryptophan biosynthesis. A 'new' PRAI was evolved from an 'old' IGPS by random mutagenesis followed by DNA shuffling and in vivo selection.

Original languageEnglish (US)
Pages (from-to)171-173
Number of pages3
JournalNature Structural Biology
Issue number3
StatePublished - Mar 1 2000

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Genetics


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