Abstract
Phosphoribosylanthranilate isomerase (PRAI) and indole-3-glycerol phosphate synthase (IGPS) are distantly related α/β-barrel enzymes that catalyze successive steps in tryptophan biosynthesis. A 'new' PRAI was evolved from an 'old' IGPS by random mutagenesis followed by DNA shuffling and in vivo selection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 171-173 |
| Number of pages | 3 |
| Journal | Nature Structural Biology |
| Volume | 7 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2000 |
ASJC Scopus subject areas
- Structural Biology
- Biochemistry
- Genetics