Abstract
Diclazuril, a triazine-based antiprotozoal agent, may have clinical application in the treatment of equine protozoal myeloencephalitis (EPM). Diclazuril was rapidly absorbed, with peak plasma concentrations occurring at 8 to 24 hours after oral-mucosal administration of diclazuril sodium salt. The mean oral bioavailability of diclazuril as Clinacox was 9.5% relative to oral-mucosal administration of diclazuril sodium salt; diclazuril in dimethyl sulfoxide administered orally was 50% less bioavailable than with oral-mucosal administration of diclazuril sodium salt. Diclazuril sodium salt has the potential to be used as a feed additive for the treatment and prophylaxis of EPM and various other apicomplexan-mediated diseases.
Original language | English (US) |
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Pages (from-to) | 52-63+72 |
Journal | Veterinary Therapeutics |
Volume | 7 |
Issue number | 1 |
State | Published - Mar 2006 |
Externally published | Yes |
ASJC Scopus subject areas
- General Veterinary