New technology for high-speed and high-resolution optical coherence tomography

J. G. Fujimoto; B. Bouma; G. J. Tearney; S. A. Boppart; C. Pitris; J. F. Southern; M. E. Brezinski

doi:10.1111/j.1749-6632.1998.tb08190.x

New technology for high-speed and high-resolution optical coherence tomography

J. G. Fujimoto, B. Bouma, G. J. Tearney, S. A. Boppart, C. Pitris, J. F. Southern, M. E. Brezinski

Research output: Contribution to journal › Article › peer-review

Abstract

Optical coherence tomography (OCT) is an optical imaging technique that is capable of performing micron-scale, cross-sectional imaging of internal microstructure in biological systems. OCT is analogous to ultrasound B mode imaging except that it uses light rather than sound and performs imaging by measuring the backscattered intensity of light from structures in tissue. We describe recent advances in OCT technology including the application of short pulse solid state lasers based on Ti:Al₂O₃ and Cr:Mg₂SiO₄ to enable high-resolution, high-speed imaging as well as the development of OCT catheter/endoscope delivery to permit imaging of internal organ systems. OCT enables the nonexcisional, in situ, real-time imaging of tissue microstructure and is thus a powerful and promising technique for optical biopsy.

Original language	English (US)
Pages (from-to)	95-107
Number of pages	13
Journal	Annals of the New York Academy of Sciences
Volume	838
DOIs	https://doi.org/10.1111/j.1749-6632.1998.tb08190.x
State	Published - Feb 9 1998
Externally published	Yes

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

Online availability

10.1111/j.1749-6632.1998.tb08190.x

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AU - Fujimoto, J. G.

AU - Bouma, B.

AU - Tearney, G. J.

AU - Boppart, S. A.

AU - Pitris, C.

AU - Southern, J. F.

AU - Brezinski, M. E.

PY - 1998/2/9

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AB - Optical coherence tomography (OCT) is an optical imaging technique that is capable of performing micron-scale, cross-sectional imaging of internal microstructure in biological systems. OCT is analogous to ultrasound B mode imaging except that it uses light rather than sound and performs imaging by measuring the backscattered intensity of light from structures in tissue. We describe recent advances in OCT technology including the application of short pulse solid state lasers based on Ti:Al2O3 and Cr:Mg2SiO4 to enable high-resolution, high-speed imaging as well as the development of OCT catheter/endoscope delivery to permit imaging of internal organ systems. OCT enables the nonexcisional, in situ, real-time imaging of tissue microstructure and is thus a powerful and promising technique for optical biopsy.

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New technology for high-speed and high-resolution optical coherence tomography

Abstract

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