Abstract

Understanding the signals that guide neuronal development and direct formation of axons, dendrites, and synapses during wiring of the brain is a fundamental challenge in developmental neuroscience. Discovery of how local signals shape developing neurons has been impeded by the inability of conventional culture methods to interrogate microenvironments of complex neuronal cytoarchitectures, where different subdomains encounter distinct chemical, physical, and fluidic features. Microfabrication techniques are facilitating the creation of microenvironments tailored to neuronal structures and subdomains with unprecedented access and control. The design, fabrication, and properties of microfluidic devices offer significant advantages for addressing unresolved issues of neuronal development. These high-resolution approaches are poised to contribute new insights into mechanisms for restoring neuronal function and connectivity compromised by injury, stress, and neurodegeneration.

Original languageEnglish (US)
Pages (from-to)752-761
Number of pages10
JournalTrends in Neurosciences
Volume35
Issue number12
DOIs
StatePublished - Dec 1 2012

Keywords

  • Axon guidance
  • Dendrite
  • Developmental neuroscience
  • Microfluidic devices
  • Neuronal polarity
  • Synapse

ASJC Scopus subject areas

  • Neuroscience(all)

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