Abstract
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a large group of structurally diverse natural products. Their biological activities and unique biosynthetic pathways have sparked a growing interest in RiPPs. Furthermore, the relatively low genetic complexity associated with RiPP biosynthesis makes them excellent candidates for synthetic biology applications. This Review highlights recent developments in the understanding of the biosynthesis of several bacterial RiPP family members, the use of the RiPP biosynthetic machinery for generating novel macrocyclic peptides, and the implementation of tools designed to guide the discovery and characterization of novel RiPPs.
Original language | English (US) |
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Pages (from-to) | 31-44 |
Number of pages | 14 |
Journal | Cell chemical biology |
Volume | 23 |
Issue number | 1 |
DOIs | |
State | Published - Jan 21 2016 |
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ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmacology
- Drug Discovery
- Clinical Biochemistry
Cite this
New Insights into the Biosynthetic Logic of Ribosomally Synthesized and Post-translationally Modified Peptide Natural Products. / Ortega, Manuel A.; van der Donk, Wilfred Adrianus.
In: Cell chemical biology, Vol. 23, No. 1, 21.01.2016, p. 31-44.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - New Insights into the Biosynthetic Logic of Ribosomally Synthesized and Post-translationally Modified Peptide Natural Products
AU - Ortega, Manuel A.
AU - van der Donk, Wilfred Adrianus
PY - 2016/1/21
Y1 - 2016/1/21
N2 - Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a large group of structurally diverse natural products. Their biological activities and unique biosynthetic pathways have sparked a growing interest in RiPPs. Furthermore, the relatively low genetic complexity associated with RiPP biosynthesis makes them excellent candidates for synthetic biology applications. This Review highlights recent developments in the understanding of the biosynthesis of several bacterial RiPP family members, the use of the RiPP biosynthetic machinery for generating novel macrocyclic peptides, and the implementation of tools designed to guide the discovery and characterization of novel RiPPs.
AB - Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a large group of structurally diverse natural products. Their biological activities and unique biosynthetic pathways have sparked a growing interest in RiPPs. Furthermore, the relatively low genetic complexity associated with RiPP biosynthesis makes them excellent candidates for synthetic biology applications. This Review highlights recent developments in the understanding of the biosynthesis of several bacterial RiPP family members, the use of the RiPP biosynthetic machinery for generating novel macrocyclic peptides, and the implementation of tools designed to guide the discovery and characterization of novel RiPPs.
UR - http://www.scopus.com/inward/record.url?scp=84965034936&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84965034936&partnerID=8YFLogxK
U2 - 10.1016/j.chembiol.2015.11.012
DO - 10.1016/j.chembiol.2015.11.012
M3 - Review article
C2 - 26933734
AN - SCOPUS:84965034936
VL - 23
SP - 31
EP - 44
JO - Cell Chemical Biology
JF - Cell Chemical Biology
SN - 2451-9448
IS - 1
ER -