TY - JOUR
T1 - New Insights into the Biosynthetic Logic of Ribosomally Synthesized and Post-translationally Modified Peptide Natural Products
AU - Ortega, Manuel A.
AU - Van Der Donk, Wilfred A.
N1 - Funding Information:
The authors acknowledge Kenton Hetrick for helpful comments. Our work on lanthipeptides is supported by the National Institutes of Health ( R01 GM0058822 ).
Publisher Copyright:
© 2016 Elsevier Ltd. All rights reserved.
PY - 2016/1/21
Y1 - 2016/1/21
N2 - Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a large group of structurally diverse natural products. Their biological activities and unique biosynthetic pathways have sparked a growing interest in RiPPs. Furthermore, the relatively low genetic complexity associated with RiPP biosynthesis makes them excellent candidates for synthetic biology applications. This Review highlights recent developments in the understanding of the biosynthesis of several bacterial RiPP family members, the use of the RiPP biosynthetic machinery for generating novel macrocyclic peptides, and the implementation of tools designed to guide the discovery and characterization of novel RiPPs.
AB - Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a large group of structurally diverse natural products. Their biological activities and unique biosynthetic pathways have sparked a growing interest in RiPPs. Furthermore, the relatively low genetic complexity associated with RiPP biosynthesis makes them excellent candidates for synthetic biology applications. This Review highlights recent developments in the understanding of the biosynthesis of several bacterial RiPP family members, the use of the RiPP biosynthetic machinery for generating novel macrocyclic peptides, and the implementation of tools designed to guide the discovery and characterization of novel RiPPs.
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U2 - 10.1016/j.chembiol.2015.11.012
DO - 10.1016/j.chembiol.2015.11.012
M3 - Review article
C2 - 26933734
AN - SCOPUS:84965034936
SN - 2451-9448
VL - 23
SP - 31
EP - 44
JO - Cell Chemical Biology
JF - Cell Chemical Biology
IS - 1
ER -