New developments in post-transcriptional regulation for operons by small RNAs

Divya Balasubramanian, Carin K. Vanderpool

Research output: Contribution to journalReview articlepeer-review


Small regulatory RNAs (sRNAs) are influential post-transcriptional modulators of gene expression in bacteria. They regulate gene expression by base pairing to target mRNAs, leading to inhibition of translation and/or alteration of mRNA stability. Recently, several sRNAs have been discovered to regulate genes encoded in operons. In some cases, these sRNAs regulate all the genes encoded by the polycistronic mRNA (coordinate regulation) while in other cases, only a select subset of cistrons is controlled by the sRNA (discoordinate regulation). In this point of view, mechanisms of regulation and characteristics of sRNA-mRNA interactions involving polycistronic mRNAs are described. The diversity in mechanisms represented by these few characterized examples suggests that we still have much to learn about sRNA regulation of long polycistronic messages.

Original languageEnglish (US)
Pages (from-to)337-341
Number of pages5
JournalRNA Biology
Issue number3
StatePublished - Mar 2013


  • Hfq
  • Polycistronic
  • RyhB
  • SgrS
  • Spot 42
  • Translational inhibition

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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