TY - JOUR
T1 - Neutrophils in cancer
T2 - dual roles through intercellular interactions
AU - Yu, Xinyu
AU - Li, Changhui
AU - Wang, Zijin
AU - Xu, Yaping
AU - Shao, Shiqun
AU - Shao, Fangwei
AU - Wang, Hua
AU - Liu, Jian
N1 - This work was supported by grants to JL from the Natural Science Foundation (NSF) of China (General Grant: 82172899), the NSF of Zhejiang Province (Distinguished Young Scholars: LR22H160002), Dr. Li Dak Sum & Yip Yio Chin Development Fund for Regenerative Medicine, Zhejiang University, and Dynamic Research Enterprise for Multidisciplinary Engineering Sciences (DREMES) at Zhejiang University and the University of Illinois at Urbana-Champaign, funded by Zhejiang University.
This work was supported by Zhejiang University-University of Edinburgh Institute (ZJE) and Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University. We also acknowledge the help of members in JL\u2019s lab.
PY - 2024/4/12
Y1 - 2024/4/12
N2 - Neutrophils, the most abundant immune cells in human blood, play crucial and diverse roles in tumor development. In the tumor microenvironment (TME), cancer cells regulate the recruitment and behaviors of neutrophils, transforming some of them into a pro-tumor phenotype. Pro-tumor neutrophils interact with cancer cells in various ways to promote cancer initiation, growth, and metastasis, while anti-tumor neutrophils interact with cancer cells to induce senescence and death. Neutrophils can also interact with other cells in TME, including T cells, macrophages, stromal cells, etc. to exert anti- or pro-tumor functions. In this review, we will analyze the anti- and pro-tumor intercellular interactions mediated by neutrophils, with a focus on generalizing the mechanisms underlying the interaction of neutrophils with tumor cells and T cells. Furthermore, we will provide an overview of cancer treatment strategies targeting neutrophil-mediated cellular interactions.
AB - Neutrophils, the most abundant immune cells in human blood, play crucial and diverse roles in tumor development. In the tumor microenvironment (TME), cancer cells regulate the recruitment and behaviors of neutrophils, transforming some of them into a pro-tumor phenotype. Pro-tumor neutrophils interact with cancer cells in various ways to promote cancer initiation, growth, and metastasis, while anti-tumor neutrophils interact with cancer cells to induce senescence and death. Neutrophils can also interact with other cells in TME, including T cells, macrophages, stromal cells, etc. to exert anti- or pro-tumor functions. In this review, we will analyze the anti- and pro-tumor intercellular interactions mediated by neutrophils, with a focus on generalizing the mechanisms underlying the interaction of neutrophils with tumor cells and T cells. Furthermore, we will provide an overview of cancer treatment strategies targeting neutrophil-mediated cellular interactions.
UR - http://www.scopus.com/inward/record.url?scp=85187478058&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85187478058&partnerID=8YFLogxK
U2 - 10.1038/s41388-024-03004-5
DO - 10.1038/s41388-024-03004-5
M3 - Review article
C2 - 38472320
AN - SCOPUS:85187478058
SN - 0950-9232
VL - 43
SP - 1163
EP - 1177
JO - Oncogene
JF - Oncogene
IS - 16
ER -