Neutrophils in cancer: dual roles through intercellular interactions

Xinyu Yu, Changhui Li, Zijin Wang, Yaping Xu, Shiqun Shao, Fangwei Shao, Hua Wang, Jian Liu

Research output: Contribution to journalReview articlepeer-review

Abstract

Neutrophils, the most abundant immune cells in human blood, play crucial and diverse roles in tumor development. In the tumor microenvironment (TME), cancer cells regulate the recruitment and behaviors of neutrophils, transforming some of them into a pro-tumor phenotype. Pro-tumor neutrophils interact with cancer cells in various ways to promote cancer initiation, growth, and metastasis, while anti-tumor neutrophils interact with cancer cells to induce senescence and death. Neutrophils can also interact with other cells in TME, including T cells, macrophages, stromal cells, etc. to exert anti- or pro-tumor functions. In this review, we will analyze the anti- and pro-tumor intercellular interactions mediated by neutrophils, with a focus on generalizing the mechanisms underlying the interaction of neutrophils with tumor cells and T cells. Furthermore, we will provide an overview of cancer treatment strategies targeting neutrophil-mediated cellular interactions.

Original languageEnglish (US)
Pages (from-to)1163-1177
Number of pages15
JournalOncogene
Volume43
Issue number16
DOIs
StatePublished - Apr 12 2024

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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