Neutron scattering in the biological sciences: progress and prospects

Rana Ashkar; Hassina Z. Bilheux; Heliosa Bordallo; Robert Briber; David J.E. Callaway; Xiaolin Cheng; Xiang Qiang Chu; Joseph E. Curtis; Mark Dadmun; Paul Fenimore; David Fushman; Frank Gabel; Kushol Gupta; Frederick Herberle; Frank Heinrich; Liang Hong; John Katsaras; Zvi Kelman; Eugenia Kharlampieva; Gerald R. Kneller; Andrey Kovalevsky; Susan Krueger; Paul Langan; Raquel Lieberman; Yun Liu; Mathias Losche; Edward Lyman; Yimin Mao; John Marino; Carla Mattos; Flora Meilleur; Peter Moody; Jonathan D. Nickels; William B. O'Dell; Hugh O'Neill; Ursula Perez-Salas; Judith Peters; Loukas Petridis; Alexei P. Sokolov; Christopher Stanley; Norman Wagner; Michael Weinrich; Kevin Weiss; Troy Wymore; Yang Zhang; Jeremy C. Smith

doi:10.1107/S2059798318017503

Neutron scattering in the biological sciences: progress and prospects

Rana Ashkar
, Hassina Z. Bilheux
, Heliosa Bordallo
, Robert Briber
, David J.E. Callaway
, Xiaolin Cheng
, Xiang Qiang Chu
, Joseph E. Curtis
, Mark Dadmun
, Paul Fenimore
, David Fushman
, Frank Gabel
, Kushol Gupta
, Frederick Herberle
, Frank Heinrich
, Liang Hong
, John Katsaras
, Zvi Kelman
, Eugenia Kharlampieva
, Gerald R. Kneller

Andrey Kovalevsky, Susan Krueger, Paul Langan, Raquel Lieberman, Yun Liu, Mathias Losche, Edward Lyman, Yimin Mao, John Marino, Carla Mattos, Flora Meilleur, Peter Moody, Jonathan D. Nickels, William B. O'Dell, Hugh O'Neill, Ursula Perez-Salas, Judith Peters, Loukas Petridis, Alexei P. Sokolov, Christopher Stanley, Norman Wagner, Michael Weinrich, Kevin Weiss, Troy Wymore, Yang Zhang, Jeremy C. Smith

Research output: Contribution to journal › Review article › peer-review

Abstract

The scattering of neutrons can be used to provide information on the structure and dynamics of biological systems on multiple length and time scales. Pursuant to a National Science Foundation-funded workshop in February 2018, recent developments in this field are reviewed here, as well as future prospects that can be expected given recent advances in sources, instrumentation and computational power and methods. Crystallography, solution scattering, dynamics, membranes, labeling and imaging are examined. For the extraction of maximum information, the incorporation of judicious specific deuterium labeling, the integration of several types of experiment, and interpretation using high-performance computer simulation models are often found to be particularly powerful.

Original language	English (US)
Pages (from-to)	1129-1168
Number of pages	40
Journal	Acta Crystallographica Section D: Structural Biology
Volume	74
Issue number	12
DOIs	https://doi.org/10.1107/S2059798318017503
State	Published - Dec 2018

Keywords

biological systems
neutron scattering
structure and dynamics

ASJC Scopus subject areas

Structural Biology

Online availability

10.1107/S2059798318017503

Library availability

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Ashkar, R., Bilheux, H. Z., Bordallo, H., Briber, R., Callaway, D. J. E., Cheng, X., Chu, X. Q., Curtis, J. E., Dadmun, M., Fenimore, P., Fushman, D., Gabel, F., Gupta, K., Herberle, F., Heinrich, F., Hong, L., Katsaras, J., Kelman, Z., Kharlampieva, E., ... Smith, J. C. (2018). Neutron scattering in the biological sciences: progress and prospects. Acta Crystallographica Section D: Structural Biology, 74(12), 1129-1168. https://doi.org/10.1107/S2059798318017503

Ashkar, R, Bilheux, HZ, Bordallo, H, Briber, R, Callaway, DJE, Cheng, X, Chu, XQ, Curtis, JE, Dadmun, M, Fenimore, P, Fushman, D, Gabel, F, Gupta, K, Herberle, F, Heinrich, F, Hong, L, Katsaras, J, Kelman, Z, Kharlampieva, E, Kneller, GR, Kovalevsky, A, Krueger, S, Langan, P, Lieberman, R, Liu, Y, Losche, M, Lyman, E, Mao, Y, Marino, J, Mattos, C, Meilleur, F, Moody, P, Nickels, JD, O'Dell, WB, O'Neill, H, Perez-Salas, U, Peters, J, Petridis, L, Sokolov, AP, Stanley, C, Wagner, N, Weinrich, M, Weiss, K, Wymore, T, Zhang, Y & Smith, JC 2018, 'Neutron scattering in the biological sciences: progress and prospects', Acta Crystallographica Section D: Structural Biology, vol. 74, no. 12, pp. 1129-1168. https://doi.org/10.1107/S2059798318017503

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title = "Neutron scattering in the biological sciences: progress and prospects",

abstract = "The scattering of neutrons can be used to provide information on the structure and dynamics of biological systems on multiple length and time scales. Pursuant to a National Science Foundation-funded workshop in February 2018, recent developments in this field are reviewed here, as well as future prospects that can be expected given recent advances in sources, instrumentation and computational power and methods. Crystallography, solution scattering, dynamics, membranes, labeling and imaging are examined. For the extraction of maximum information, the incorporation of judicious specific deuterium labeling, the integration of several types of experiment, and interpretation using high-performance computer simulation models are often found to be particularly powerful.",

keywords = "biological systems, neutron scattering, structure and dynamics",

author = "Rana Ashkar and Bilheux, \{Hassina Z.\} and Heliosa Bordallo and Robert Briber and Callaway, \{David J.E.\} and Xiaolin Cheng and Chu, \{Xiang Qiang\} and Curtis, \{Joseph E.\} and Mark Dadmun and Paul Fenimore and David Fushman and Frank Gabel and Kushol Gupta and Frederick Herberle and Frank Heinrich and Liang Hong and John Katsaras and Zvi Kelman and Eugenia Kharlampieva and Kneller, \{Gerald R.\} and Andrey Kovalevsky and Susan Krueger and Paul Langan and Raquel Lieberman and Yun Liu and Mathias Losche and Edward Lyman and Yimin Mao and John Marino and Carla Mattos and Flora Meilleur and Peter Moody and Nickels, \{Jonathan D.\} and O'Dell, \{William B.\} and Hugh O'Neill and Ursula Perez-Salas and Judith Peters and Loukas Petridis and Sokolov, \{Alexei P.\} and Christopher Stanley and Norman Wagner and Michael Weinrich and Kevin Weiss and Troy Wymore and Yang Zhang and Smith, \{Jeremy C.\}",

note = "The authors thank the National Science Foundation for funding the workshop that led to this article. The workshop was chaired by Jeremy C. Smith and Mark Dadmun. The attendees thank Adam Green and Lora Davis for logistical support. This manuscript has been authored by UT-Battelle LLC under Contract No. DE-AC05-00OR22725 with the US Department of Energy. The United States Government retains and the publisher, by accepting the article for publication, acknowledges that the United States Government retains a non-exclusive, paid-up, irrevocable, worldwide license to publish or reproduce the published form of this manuscript, or allow others to do so, for United States Government purposes. The Department of Energy will provide public access to these results of federally sponsored research in accordance with the DOE Public Access Plan (http://energy.gov/downloads/ doe-public-access-plan).",

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doi = "10.1107/S2059798318017503",

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journal = "Acta Crystallographica Section D: Structural Biology",

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T1 - Neutron scattering in the biological sciences

T2 - progress and prospects

AU - Ashkar, Rana

AU - Bilheux, Hassina Z.

AU - Bordallo, Heliosa

AU - Briber, Robert

AU - Callaway, David J.E.

AU - Cheng, Xiaolin

AU - Chu, Xiang Qiang

AU - Curtis, Joseph E.

AU - Dadmun, Mark

AU - Fenimore, Paul

AU - Fushman, David

AU - Gabel, Frank

AU - Gupta, Kushol

AU - Herberle, Frederick

AU - Heinrich, Frank

AU - Hong, Liang

AU - Katsaras, John

AU - Kelman, Zvi

AU - Kharlampieva, Eugenia

AU - Kneller, Gerald R.

AU - Kovalevsky, Andrey

AU - Krueger, Susan

AU - Langan, Paul

AU - Lieberman, Raquel

AU - Liu, Yun

AU - Losche, Mathias

AU - Lyman, Edward

AU - Mao, Yimin

AU - Marino, John

AU - Mattos, Carla

AU - Meilleur, Flora

AU - Moody, Peter

AU - Nickels, Jonathan D.

AU - O'Dell, William B.

AU - O'Neill, Hugh

AU - Perez-Salas, Ursula

AU - Peters, Judith

AU - Petridis, Loukas

AU - Sokolov, Alexei P.

AU - Stanley, Christopher

AU - Wagner, Norman

AU - Weinrich, Michael

AU - Weiss, Kevin

AU - Wymore, Troy

AU - Zhang, Yang

AU - Smith, Jeremy C.

N1 - The authors thank the National Science Foundation for funding the workshop that led to this article. The workshop was chaired by Jeremy C. Smith and Mark Dadmun. The attendees thank Adam Green and Lora Davis for logistical support. This manuscript has been authored by UT-Battelle LLC under Contract No. DE-AC05-00OR22725 with the US Department of Energy. The United States Government retains and the publisher, by accepting the article for publication, acknowledges that the United States Government retains a non-exclusive, paid-up, irrevocable, worldwide license to publish or reproduce the published form of this manuscript, or allow others to do so, for United States Government purposes. The Department of Energy will provide public access to these results of federally sponsored research in accordance with the DOE Public Access Plan (http://energy.gov/downloads/ doe-public-access-plan).

PY - 2018/12

Y1 - 2018/12

N2 - The scattering of neutrons can be used to provide information on the structure and dynamics of biological systems on multiple length and time scales. Pursuant to a National Science Foundation-funded workshop in February 2018, recent developments in this field are reviewed here, as well as future prospects that can be expected given recent advances in sources, instrumentation and computational power and methods. Crystallography, solution scattering, dynamics, membranes, labeling and imaging are examined. For the extraction of maximum information, the incorporation of judicious specific deuterium labeling, the integration of several types of experiment, and interpretation using high-performance computer simulation models are often found to be particularly powerful.

AB - The scattering of neutrons can be used to provide information on the structure and dynamics of biological systems on multiple length and time scales. Pursuant to a National Science Foundation-funded workshop in February 2018, recent developments in this field are reviewed here, as well as future prospects that can be expected given recent advances in sources, instrumentation and computational power and methods. Crystallography, solution scattering, dynamics, membranes, labeling and imaging are examined. For the extraction of maximum information, the incorporation of judicious specific deuterium labeling, the integration of several types of experiment, and interpretation using high-performance computer simulation models are often found to be particularly powerful.

KW - biological systems

KW - neutron scattering

KW - structure and dynamics

UR - https://www.scopus.com/pages/publications/85059502338

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U2 - 10.1107/S2059798318017503

DO - 10.1107/S2059798318017503

M3 - Review article

C2 - 30605130

AN - SCOPUS:85059502338

SN - 0907-4449

VL - 74

SP - 1129

EP - 1168

JO - Acta Crystallographica Section D: Structural Biology

JF - Acta Crystallographica Section D: Structural Biology

IS - 12

ER -

Neutron scattering in the biological sciences: progress and prospects

Abstract

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