Neurotoxicity of Halogenated O-Phenyl O-Alkyl Alkylphosphonothioates

Research output: Contribution to journalArticle

Abstract

Twenty-seven halogenated organophosphorus esters were tested for neurotoxicity in adult hens. Fourteen compounds were overtly neurotoxic, including eight OF eleven methylphosphonothioates, three of seven ethylphosphonothioates, and three of six phosphorami-dates, one of which was the commercial herbicide DMPA. Neurotoxic activity varied both with the number of halogen substituents on the phenyl group, and with the identity of the 4-phenyl halogen, Neurotoxic activity also varied with the alkyl group involved in the P-C or P-N bond, and with the identity of the 0-alkyl group.

Original languageEnglish (US)
Pages (from-to)313-331
Number of pages19
JournalJournal of Environmental Science and Health, Part B
Volume15
Issue number4
DOIs
StatePublished - Jan 1 1980

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halogens
Halogens
neurotoxicity
Herbicides
halogen
Esters
ester
herbicide
hens
herbicides
esters
N,N-dimethyl-4-anisidine

Keywords

  • Neurotoxicity
  • Organophosphorus esters

ASJC Scopus subject areas

  • Food Science
  • Pollution
  • Environmental Science(all)
  • Environmental Chemistry
  • Waste Management and Disposal
  • Public Health, Environmental and Occupational Health

Cite this

Neurotoxicity of Halogenated O-Phenyl O-Alkyl Alkylphosphonothioates. / Francis, Bettina M.

In: Journal of Environmental Science and Health, Part B, Vol. 15, No. 4, 01.01.1980, p. 313-331.

Research output: Contribution to journalArticle

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