Twenty-seven halogenated organophosphorus esters were tested for neurotoxicity in adult hens. Fourteen compounds were overtly neurotoxic, including eight OF eleven methylphosphonothioates, three of seven ethylphosphonothioates, and three of six phosphorami-dates, one of which was the commercial herbicide DMPA. Neurotoxic activity varied both with the number of halogen substituents on the phenyl group, and with the identity of the 4-phenyl halogen, Neurotoxic activity also varied with the alkyl group involved in the P-C or P-N bond, and with the identity of the 0-alkyl group.
|Original language||English (US)|
|Number of pages||19|
|Journal||Journal of Environmental Science and Health, Part B|
|State||Published - Jan 1 1980|
- Organophosphorus esters
ASJC Scopus subject areas
- Food Science