Neuroprotective effects of estrogens following ischemic stroke

Shotaro Suzuki, Candice M. Brown, Phyllis M. Wise

Research output: Contribution to journalReview articlepeer-review


Our laboratory has investigated whether and how 17β-estradiol (E2) protects the brain against neurodegeneration associated with cerebrovascular stroke. We have discovered that low, physiological concentrations of E2, which are strikingly similar to low-basal circulating levels found in cycling mice, dramatically protect the brain against stroke injury, and consequently revealed multiple signaling pathways and key genes that mediate protective action of E2. Here we will review the discoveries comprising our current understanding of neuroprotective actions of estrogens against ischemic stroke. These findings may carry far reaching implications for improving the quality of life in aging populations.

Original languageEnglish (US)
Pages (from-to)201-211
Number of pages11
JournalFrontiers in Neuroendocrinology
Issue number2
StatePublished - Jul 2009
Externally publishedYes


  • 17β-Estradiol
  • Estrogen receptor
  • Estrogen therapy
  • Inflammation
  • Ischemia
  • Middle cerebral artery occlusion
  • Neurogenesis
  • Stroke
  • Women's health initiative

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems


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