Neuroprotective effects of estrogens following ischemic stroke

Shotaro Suzuki, Candice M. Brown, Phyllis M. Wise

    Research output: Contribution to journalReview articlepeer-review

    Abstract

    Our laboratory has investigated whether and how 17β-estradiol (E2) protects the brain against neurodegeneration associated with cerebrovascular stroke. We have discovered that low, physiological concentrations of E2, which are strikingly similar to low-basal circulating levels found in cycling mice, dramatically protect the brain against stroke injury, and consequently revealed multiple signaling pathways and key genes that mediate protective action of E2. Here we will review the discoveries comprising our current understanding of neuroprotective actions of estrogens against ischemic stroke. These findings may carry far reaching implications for improving the quality of life in aging populations.

    Original languageEnglish (US)
    Pages (from-to)201-211
    Number of pages11
    JournalFrontiers in Neuroendocrinology
    Volume30
    Issue number2
    DOIs
    StatePublished - Jul 2009

    Keywords

    • 17β-Estradiol
    • Estrogen receptor
    • Estrogen therapy
    • Inflammation
    • Ischemia
    • Middle cerebral artery occlusion
    • Neurogenesis
    • Stroke
    • Women's health initiative

    ASJC Scopus subject areas

    • Endocrine and Autonomic Systems

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