Neuroprotective effects of estrogens following ischemic stroke

Shotaro Suzuki; Candice M. Brown; Phyllis M. Wise

doi:10.1016/j.yfrne.2009.04.007

Neuroprotective effects of estrogens following ischemic stroke

Shotaro Suzuki, Candice M. Brown, Phyllis M. Wise

Research output: Contribution to journal › Review article › peer-review

Abstract

Our laboratory has investigated whether and how 17β-estradiol (E₂) protects the brain against neurodegeneration associated with cerebrovascular stroke. We have discovered that low, physiological concentrations of E₂, which are strikingly similar to low-basal circulating levels found in cycling mice, dramatically protect the brain against stroke injury, and consequently revealed multiple signaling pathways and key genes that mediate protective action of E₂. Here we will review the discoveries comprising our current understanding of neuroprotective actions of estrogens against ischemic stroke. These findings may carry far reaching implications for improving the quality of life in aging populations.

Original language	English (US)
Pages (from-to)	201-211
Number of pages	11
Journal	Frontiers in Neuroendocrinology
Volume	30
Issue number	2
DOIs	https://doi.org/10.1016/j.yfrne.2009.04.007
State	Published - Jul 2009
Externally published	Yes

Keywords

17β-Estradiol
Estrogen receptor
Estrogen therapy
Inflammation
Ischemia
Middle cerebral artery occlusion
Neurogenesis
Stroke
Women's health initiative

ASJC Scopus subject areas

Endocrine and Autonomic Systems

Online availability

10.1016/j.yfrne.2009.04.007

Library availability

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title = "Neuroprotective effects of estrogens following ischemic stroke",

abstract = "Our laboratory has investigated whether and how 17β-estradiol (E2) protects the brain against neurodegeneration associated with cerebrovascular stroke. We have discovered that low, physiological concentrations of E2, which are strikingly similar to low-basal circulating levels found in cycling mice, dramatically protect the brain against stroke injury, and consequently revealed multiple signaling pathways and key genes that mediate protective action of E2. Here we will review the discoveries comprising our current understanding of neuroprotective actions of estrogens against ischemic stroke. These findings may carry far reaching implications for improving the quality of life in aging populations.",

keywords = "17β-Estradiol, Estrogen receptor, Estrogen therapy, Inflammation, Ischemia, Middle cerebral artery occlusion, Neurogenesis, Stroke, Women's health initiative",

author = "Shotaro Suzuki and Brown, {Candice M.} and Wise, {Phyllis M.}",

note = "Funding Information: This work was supported by National Institutes of Health Grant AG17164 and 02224 (P.M.W.), American Heart Association Postdoctoral Fellowship 0920086G (S.S.) and a Ruth L. Kirschstein NRSA Postdoctoral Fellowship AG 27614 (C.M.B.).",

year = "2009",

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AU - Brown, Candice M.

AU - Wise, Phyllis M.

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PY - 2009/7

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N2 - Our laboratory has investigated whether and how 17β-estradiol (E2) protects the brain against neurodegeneration associated with cerebrovascular stroke. We have discovered that low, physiological concentrations of E2, which are strikingly similar to low-basal circulating levels found in cycling mice, dramatically protect the brain against stroke injury, and consequently revealed multiple signaling pathways and key genes that mediate protective action of E2. Here we will review the discoveries comprising our current understanding of neuroprotective actions of estrogens against ischemic stroke. These findings may carry far reaching implications for improving the quality of life in aging populations.

AB - Our laboratory has investigated whether and how 17β-estradiol (E2) protects the brain against neurodegeneration associated with cerebrovascular stroke. We have discovered that low, physiological concentrations of E2, which are strikingly similar to low-basal circulating levels found in cycling mice, dramatically protect the brain against stroke injury, and consequently revealed multiple signaling pathways and key genes that mediate protective action of E2. Here we will review the discoveries comprising our current understanding of neuroprotective actions of estrogens against ischemic stroke. These findings may carry far reaching implications for improving the quality of life in aging populations.

KW - 17β-Estradiol

KW - Estrogen receptor

KW - Estrogen therapy

KW - Inflammation

KW - Ischemia

KW - Middle cerebral artery occlusion

KW - Neurogenesis

KW - Stroke

KW - Women's health initiative

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Neuroprotective effects of estrogens following ischemic stroke

Abstract

Keywords

ASJC Scopus subject areas

Online availability

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