Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson's disease

Katherine E. Strathearn, Gad G. Yousef, Mary H. Grace, Susan L. Roy, Mitali A. Tambe, Mario G. Ferruzzi, Qing Li Wu, James E. Simon, Mary Ann Lila, Jean Christophe Rochet

Research output: Contribution to journalArticlepeer-review

Abstract

Neuropathological evidence indicates that dopaminergic cell death in Parkinson's disease (PD) involves impairment of mitochondrial complex I, oxidative stress, microglial activation, and the formation of Lewy bodies. Epidemiological findings suggest that the consumption of berries rich in anthocyanins and proanthocyanidins may reduce PD risk. In this study, we investigated whether extracts rich in anthocyanins, proanthocyanidins, or other polyphenols suppress the neurotoxic effects of rotenone in a primary cell culture model of PD. Dopaminergic cell death elicited by rotenone was suppressed by extracts prepared from blueberries, grape seed, hibiscus, blackcurrant, and Chinese mulberry. Extracts rich in anthocyanins and proanthocyanidins exhibited greater neuroprotective activity than extracts rich in other polyphenols, and a number of individual anthocyanins interfered with rotenone neurotoxicity. The blueberry and grape seed extracts rescued rotenone-induced defects in mitochondrial respiration in a dopaminergic cell line, and a purple basal extract attenuated nitrite release from microglial cells stimulated by lipopolysaccharide. These findings suggest that anthocyanin- and proanthocyanidin-rich botanical extracts may alleviate neurodegeneration in PD via enhancement of mitochondrial function.

Original languageEnglish (US)
Pages (from-to)60-77
Number of pages18
JournalBrain Research
Volume1555
DOIs
StatePublished - Mar 25 2014
Externally publishedYes

Keywords

  • Anthocyanin
  • Microglial activation
  • Mitochondria
  • Parkinson's disease
  • Proanthocyanidin
  • Rotenone

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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