Neuronal localization of indoleamine 2,3-dioxygenase in mice

Edward J. Roy; Osamu Takikawa; David M. Kranz; Alicia R. Brown; Diana L. Thomas

doi:10.1016/j.neulet.2005.07.010

Neuronal localization of indoleamine 2,3-dioxygenase in mice

Edward J. Roy, Osamu Takikawa, David M. Kranz, Alicia R. Brown, Diana L. Thomas

Research output: Contribution to journal › Article › peer-review

Abstract

Indoleamine 2,3-dioxygenase (IDO) catabolizes tryptophan to kynurenine. In the immune system, the reduction in tryptophan and increase in kynurenine act to suppress T-cell function. In the nervous system, kynurenine can be further metabolized to quinolinic acid, which can be neurotoxic. IDO is known to be expressed by microglia and its levels are upregulated by interferon-γ (IFNγ). We report here that IDO immunoreactivity is also localized in neurons, and that IDO is upregulated by IFNγ in neurons of the hippocampus. Thus, neuronal IDO could contribute to the vulnerability of neurons to inflammatory conditions.

Original language	English (US)
Pages (from-to)	95-99
Number of pages	5
Journal	Neuroscience Letters
Volume	387
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2005.07.010
State	Published - Oct 21 2005

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2005.07.010

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title = "Neuronal localization of indoleamine 2,3-dioxygenase in mice",

abstract = "Indoleamine 2,3-dioxygenase (IDO) catabolizes tryptophan to kynurenine. In the immune system, the reduction in tryptophan and increase in kynurenine act to suppress T-cell function. In the nervous system, kynurenine can be further metabolized to quinolinic acid, which can be neurotoxic. IDO is known to be expressed by microglia and its levels are upregulated by interferon-γ (IFNγ). We report here that IDO immunoreactivity is also localized in neurons, and that IDO is upregulated by IFNγ in neurons of the hippocampus. Thus, neuronal IDO could contribute to the vulnerability of neurons to inflammatory conditions.",

author = "Roy, {Edward J.} and Osamu Takikawa and Kranz, {David M.} and Brown, {Alicia R.} and Thomas, {Diana L.}",

note = "Funding Information: We would like to thank Benoit Van den Eynde for supplying the P815B cell lines. Technical assistance was provided by Melissa Goelitz. Supported by NIH grant R21 CA11001 (EJR).",

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doi = "10.1016/j.neulet.2005.07.010",

language = "English (US)",

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AU - Roy, Edward J.

AU - Takikawa, Osamu

AU - Kranz, David M.

AU - Brown, Alicia R.

AU - Thomas, Diana L.

N1 - Funding Information: We would like to thank Benoit Van den Eynde for supplying the P815B cell lines. Technical assistance was provided by Melissa Goelitz. Supported by NIH grant R21 CA11001 (EJR).

PY - 2005/10/21

Y1 - 2005/10/21

N2 - Indoleamine 2,3-dioxygenase (IDO) catabolizes tryptophan to kynurenine. In the immune system, the reduction in tryptophan and increase in kynurenine act to suppress T-cell function. In the nervous system, kynurenine can be further metabolized to quinolinic acid, which can be neurotoxic. IDO is known to be expressed by microglia and its levels are upregulated by interferon-γ (IFNγ). We report here that IDO immunoreactivity is also localized in neurons, and that IDO is upregulated by IFNγ in neurons of the hippocampus. Thus, neuronal IDO could contribute to the vulnerability of neurons to inflammatory conditions.

AB - Indoleamine 2,3-dioxygenase (IDO) catabolizes tryptophan to kynurenine. In the immune system, the reduction in tryptophan and increase in kynurenine act to suppress T-cell function. In the nervous system, kynurenine can be further metabolized to quinolinic acid, which can be neurotoxic. IDO is known to be expressed by microglia and its levels are upregulated by interferon-γ (IFNγ). We report here that IDO immunoreactivity is also localized in neurons, and that IDO is upregulated by IFNγ in neurons of the hippocampus. Thus, neuronal IDO could contribute to the vulnerability of neurons to inflammatory conditions.

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Neuronal localization of indoleamine 2,3-dioxygenase in mice

Abstract

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