Neuronal localization of indoleamine 2,3-dioxygenase in mice

Edward J Roy, Osamu Takikawa, David M Kranz, Alicia R. Brown, Diana L. Thomas

Research output: Contribution to journalArticle

Abstract

Indoleamine 2,3-dioxygenase (IDO) catabolizes tryptophan to kynurenine. In the immune system, the reduction in tryptophan and increase in kynurenine act to suppress T-cell function. In the nervous system, kynurenine can be further metabolized to quinolinic acid, which can be neurotoxic. IDO is known to be expressed by microglia and its levels are upregulated by interferon-γ (IFNγ). We report here that IDO immunoreactivity is also localized in neurons, and that IDO is upregulated by IFNγ in neurons of the hippocampus. Thus, neuronal IDO could contribute to the vulnerability of neurons to inflammatory conditions.

Original languageEnglish (US)
Pages (from-to)95-99
Number of pages5
JournalNeuroscience Letters
Volume387
Issue number2
DOIs
StatePublished - Oct 21 2005

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Indoleamine-Pyrrole 2,3,-Dioxygenase
Kynurenine
Neurons
Tryptophan
Interferons
Quinolinic Acid
Microglia
Nervous System
Immune System
Hippocampus
T-Lymphocytes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neuronal localization of indoleamine 2,3-dioxygenase in mice. / Roy, Edward J; Takikawa, Osamu; Kranz, David M; Brown, Alicia R.; Thomas, Diana L.

In: Neuroscience Letters, Vol. 387, No. 2, 21.10.2005, p. 95-99.

Research output: Contribution to journalArticle

Roy, Edward J ; Takikawa, Osamu ; Kranz, David M ; Brown, Alicia R. ; Thomas, Diana L. / Neuronal localization of indoleamine 2,3-dioxygenase in mice. In: Neuroscience Letters. 2005 ; Vol. 387, No. 2. pp. 95-99.
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