Neuromolecular responses to social challenge: Common mechanisms across mouse, stickleback fish, and honey bee

Clare C. Rittschof, Syed Abbas Bukhari, Laura G. Sloofman, Joseph M. Troy, Derek Caetano-Anollés, Amy Cash-Ahmed, Molly Kent, Xiaochen Lu, Yibayiri O. Sanogo, Patricia A. Weisner, Huimin Zhang, Alison M. Bell, Jian Ma, Saurabh Sinha, Gene E. Robinson, Lisa Stubbs

Research output: Contribution to journalArticle

Abstract

Certain complex phenotypes appear repeatedly across diverse species due to processes of evolutionary conservation and convergence. In some contexts like developmental body patterning, there is increased appreciation that common molecular mechanisms underlie common phenotypes; these molecular mechanisms include highly conserved genes and networks that may be modified by lineage-specific mutations. However, the existence of deeply conserved mechanisms for social behaviors has not yet been demonstrated. We used a comparative genomics approach to determine whether shared neuromolecular mechanisms could underlie behavioral response to territory intrusion across species spanning a broad phylogenetic range: house mouse (Mus musculus), stickleback fish (Gasterosteus aculeatus), and honey bee (Apis mellifera). Territory intrusion modulated similar brain functional processes in each species, including those associated with hormone-mediated signal transduction and neurodevelopment. Changes in chromosome organization and energy metabolism appear to be core, conserved processes involved in the response to territory intrusion. We also found that several homologous transcription factors that are typically associatedwith neural development were modulated across all three species, suggesting that shared neuronal effects may involve transcriptional cascades of evolutionarily conserved genes. Furthermore, immunohistochemical analyses of a subset of these transcription factors in mouse again implicated modulation of energy metabolism in the behavioral response. These results provide support for conserved genetic "toolkits" that are used in independent evolutions of the response to social challenge in diverse taxa.

Original languageEnglish (US)
Pages (from-to)17929-17934
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume111
Issue number50
DOIs
StatePublished - Dec 16 2014

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Smegmamorpha
Honey
Bees
Fishes
Energy Metabolism
Transcription Factors
Body Patterning
Phenotype
Social Behavior
Gene Regulatory Networks
Genomics
Signal Transduction
Chromosomes
Hormones
Mutation
Brain
Genes

Keywords

  • Aggression
  • Brain metabolism
  • Genetic hotspot
  • Nf-κb signaling

ASJC Scopus subject areas

  • General

Cite this

Neuromolecular responses to social challenge : Common mechanisms across mouse, stickleback fish, and honey bee. / Rittschof, Clare C.; Bukhari, Syed Abbas; Sloofman, Laura G.; Troy, Joseph M.; Caetano-Anollés, Derek; Cash-Ahmed, Amy; Kent, Molly; Lu, Xiaochen; Sanogo, Yibayiri O.; Weisner, Patricia A.; Zhang, Huimin; Bell, Alison M.; Ma, Jian; Sinha, Saurabh; Robinson, Gene E.; Stubbs, Lisa.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, No. 50, 16.12.2014, p. 17929-17934.

Research output: Contribution to journalArticle

Rittschof, CC, Bukhari, SA, Sloofman, LG, Troy, JM, Caetano-Anollés, D, Cash-Ahmed, A, Kent, M, Lu, X, Sanogo, YO, Weisner, PA, Zhang, H, Bell, AM, Ma, J, Sinha, S, Robinson, GE & Stubbs, L 2014, 'Neuromolecular responses to social challenge: Common mechanisms across mouse, stickleback fish, and honey bee', Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 50, pp. 17929-17934. https://doi.org/10.1073/pnas.1420369111
Rittschof, Clare C. ; Bukhari, Syed Abbas ; Sloofman, Laura G. ; Troy, Joseph M. ; Caetano-Anollés, Derek ; Cash-Ahmed, Amy ; Kent, Molly ; Lu, Xiaochen ; Sanogo, Yibayiri O. ; Weisner, Patricia A. ; Zhang, Huimin ; Bell, Alison M. ; Ma, Jian ; Sinha, Saurabh ; Robinson, Gene E. ; Stubbs, Lisa. / Neuromolecular responses to social challenge : Common mechanisms across mouse, stickleback fish, and honey bee. In: Proceedings of the National Academy of Sciences of the United States of America. 2014 ; Vol. 111, No. 50. pp. 17929-17934.
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