Neuromodulatory control of a goal-directed decision

Keiko Hirayama, Leonid L. Moroz, Nathan G. Hatcher, Rhanor Gillette

Research output: Contribution to journalArticle

Abstract

Many cost-benefit decisions reduce to simple choices between approach or avoidance (or active disregard) to salient stimuli. Physiologically, critical factors in such decisions are modulators of the homeostatic neural networks that bias decision processes from moment to moment. For the predatory sea-slug Pleurobranchaea , serotonin (5-HT) is an intrinsic modulatory promoter of general arousal and feeding. We correlated 5-HT actions on appetitive state with its effects on the approach-avoidance decision in Pleurobranchaea. 5-HT and its precursor 5-hydroxytryptophan (5-HTP) augmented general arousal state and reduced feeding thresholds in intact animals. Moreover, 5-HT switched the turn response to chemosensory stimulation from avoidance to orienting in many animals. In isolated CNSs, bath application of 5-HT both stimulated activity in the feeding motor network and switched the fictive turn response to unilateral sensory nerve stimulation from avoidance to orienting. Previously, it was shown that increasing excitation state of the feeding network reversibly switched the turn motor network response from avoidance to orienting, and that 5-HT levels vary inversely with nutritional state. A simple model posits a critical role for 5-HT in control of the turn network response by corollary output of the feeding network. In it, 5-HT acts as an intrinsic neuromodulatory factor coupled to nutritional status and regulates approach-avoidance via the excitation state of the feeding network. Thus, the neuromodulator is a key organizing element in behavioral choice of approach or avoidance through its actions in promoting appetitive state, in large part via the homeostatic feeding network.

Original languageEnglish (US)
Article numbere102240
JournalPloS one
Volume9
Issue number7
DOIs
StatePublished - Jul 21 2014

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serotonin
Serotonin
Pleurobranchaea
Arousal
nutritional status
Animals
5-hydroxytryptophan
5-Hydroxytryptophan
Intrinsic Factor
Gastropoda
slugs
Switching networks
neurotransmitters
Nutritional Status
Baths
Oceans and Seas
neural networks
Modulators
Cost-Benefit Analysis
Neurotransmitter Agents

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Neuromodulatory control of a goal-directed decision. / Hirayama, Keiko; Moroz, Leonid L.; Hatcher, Nathan G.; Gillette, Rhanor.

In: PloS one, Vol. 9, No. 7, e102240, 21.07.2014.

Research output: Contribution to journalArticle

Hirayama, Keiko ; Moroz, Leonid L. ; Hatcher, Nathan G. ; Gillette, Rhanor. / Neuromodulatory control of a goal-directed decision. In: PloS one. 2014 ; Vol. 9, No. 7.
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