TY - JOUR
T1 - Neurochemical challenge
AU - Heien, Michael L.
AU - Sweedler, Jonathan V.
PY - 2007/1
Y1 - 2007/1
N2 - The effect of neurotransmitters on the firing pattern of the postsynaptic cells with which the new neuronal type forms a synapse was investigated. Two sensors capable of detecting the different neurotransmitters which is an electrochemical sensor for neurotransmitter A and a cannula interfaced with capillary electrophoresis for detection of neurotransmitter B was developed. To determine the biological function of the neurotransmitter the electrical output of the circuit as a response to an input stimulus was measured. The detection limit of neurotransmitter A was limited to 40 nmol L-1 and the detection limit of the neurotransmitter B was 80 nmol L-1. the closest position of the dual sensor was approximately 5 μm from the synapse.
AB - The effect of neurotransmitters on the firing pattern of the postsynaptic cells with which the new neuronal type forms a synapse was investigated. Two sensors capable of detecting the different neurotransmitters which is an electrochemical sensor for neurotransmitter A and a cannula interfaced with capillary electrophoresis for detection of neurotransmitter B was developed. To determine the biological function of the neurotransmitter the electrical output of the circuit as a response to an input stimulus was measured. The detection limit of neurotransmitter A was limited to 40 nmol L-1 and the detection limit of the neurotransmitter B was 80 nmol L-1. the closest position of the dual sensor was approximately 5 μm from the synapse.
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U2 - 10.1007/s00216-006-0932-1
DO - 10.1007/s00216-006-0932-1
M3 - Article
C2 - 17111104
AN - SCOPUS:33845680794
SN - 1618-2642
VL - 387
SP - 3
EP - 4
JO - Analytical and bioanalytical chemistry
JF - Analytical and bioanalytical chemistry
IS - 1
ER -