Neuro-immune dysfunction during brain aging: new insights in microglial cell regulation

Stephanie M. Matt, Rodney W. Johnson

Research output: Contribution to journalReview articlepeer-review

Abstract

Microglia, the resident immune cells of the brain, are at the center of communication between the central nervous system and immune system. While these brain-immune interactions are balanced in healthy adulthood, the ability to maintain homeostasis during aging is impaired. Microglia develop a loss of integrated regulatory networks including aberrant signaling from other brain cells, immune sensors, and epigenetic modifiers. The low-grade chronic neuroinflammation associated with this dysfunctional activity likely contributes to cognitive deficits and susceptibility to age-related pathologies. A better understanding of the underlying mechanisms responsible for neuro-immune dysregulation with age is crucial for providing targeted therapeutic strategies to support brain repair and healthy aging.

Original languageEnglish (US)
Pages (from-to)96-101
Number of pages6
JournalCurrent Opinion in Pharmacology
Volume26
DOIs
StatePublished - Feb 2016

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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