Neuraminidase (sialidase) activity of Haemophilus parasuis

Carol A. Lichtensteiger, Eric R. Vimr

Research output: Contribution to journalArticlepeer-review


Neuraminidase (sialidase), a potential virulence factor in bacteria, was demonstrated in Haemophilus parasuis, an invasive swine pathogen, but not in four other pathogens of the Pasteurellaceae family: H. influenzae, H. somnus, H. paragallinarum, or Actinobacillus pleuropneumoniae. H. parasuis neuraminidase had an acidic pH optimum and a specificity for several substrates also cleaved by other bacterial neuraminidases. Similar to the neuraminidase of Pasteurella multocida, H. parasuis neuraminidase was cell associated and did not require divalent cations for activity. Exogenous sialic acid added to growth medium of H. parasuis was cleared after a lag of about 10 h and these cultures grew to a greater final density than cultures without added sialic acid, indicating that exogenous sialic acid is metabolized. The role of sialidase in providing nutrients to H. parasuis may be an important factor in its obligate parasitism.

Original languageEnglish (US)
Pages (from-to)269-274
Number of pages6
JournalFEMS microbiology letters
Issue number2
StatePublished - Jul 15 1997


  • Acti nobacillus
  • Haemophilus
  • Haemophilus parasuis
  • Neuraminidase
  • Pasteurella
  • Pasteurellaceae
  • Sialidase

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics


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