TY - JOUR
T1 - Neural Markers of Emotion Reactivity and Regulation Before and After a Targeted Social Rejection
T2 - Differences Among Girls With and Without Suicidal Ideation and Behavior Histories
AU - Miller, Adam Bryant
AU - Jenness, Jessica L.
AU - Elton, Amanda L.
AU - Pelletier-Baldelli, Andrea
AU - Patel, Kinjal
AU - Bonar, Adrienne
AU - Martin, Sophia
AU - Dichter, Gabriel
AU - Giletta, Matteo
AU - Slavich, George M.
AU - Rudolph, Karen D.
AU - Hastings, Paul
AU - Nock, Matthew
AU - Prinstein, Mitchell J.
AU - Sheridan, Margaret A.
N1 - Data collection and preparation of this manuscript were supported by grants from the National Institutes of Mental Health (K01MH116325; R01MH107479, R01MH107479-S1; R01MH11500; R34MH128387; K23MH112872) and National Institutes of Alcohol Abuse and Alcoholism (K01AA026334).
This work was supported by the National Institute of Mental Health (Grant Nos. K01MH116325 [to ABM], R01MH107479 [to MJP and MN], R01MH107479-S1 [to MJP], R01MH115004 [to MAS], R34MH128387 [to JLJ], and K23MH112872 [to JLJ]) and the National Institute on Alcohol Abuse and Alcoholism (Grant No. K01AA026334 [to ALE]). The authors report no biomedical financial interests or potential conflicts of interest.
PY - 2024/6/15
Y1 - 2024/6/15
N2 - Background: Suicidal thoughts and behaviors (STBs) are common among adolescent girls and increase risk for suicide death. Emotion regulation difficulties are linked with STBs, particularly in response to targeted social rejection. However, neural correlates of this link have not been investigated and may identify novel targets for interventions. Here, we examined neural correlates of emotion regulation before and after an experimentally delivered targeted social rejection in adolescent girls with STBs and girls without STBs (i.e., control participants). Methods: Girls (N = 138; age range, 9–15 years; mean [SD] age = 11.6 [1.79] years) completed a functional neuroimaging emotion regulation task. In the middle of the task, participants were socially rejected by an unfamiliar confederate whom the participants had elected to meet. Participants also completed a multimethod STB assessment. Results: Before rejection, girls with a history of STBs, compared with control participants, showed greater activation in the right superior frontal gyrus when passively viewing negative stimuli, and girls with suicidal behavior (SB) versus those without SB showed less activation in the right frontal pole during emotion regulation attempts. Following the rejection, girls with STBs, compared with control participants, showed greater activation in the right inferior frontal gyrus during emotion regulation. Conclusions: Before social rejection, girls with SB versus without SB may not activate brain regions implicated in emotion regulation, suggesting a vulnerability to poor regulation at their baseline emotional state. After social rejection, girls with any history of STBs showed altered activation in a brain region strongly associated with inhibition and emotion regulation success, possibly reflecting increased effort at inhibiting emotional responses during regulation following stress exposure.
AB - Background: Suicidal thoughts and behaviors (STBs) are common among adolescent girls and increase risk for suicide death. Emotion regulation difficulties are linked with STBs, particularly in response to targeted social rejection. However, neural correlates of this link have not been investigated and may identify novel targets for interventions. Here, we examined neural correlates of emotion regulation before and after an experimentally delivered targeted social rejection in adolescent girls with STBs and girls without STBs (i.e., control participants). Methods: Girls (N = 138; age range, 9–15 years; mean [SD] age = 11.6 [1.79] years) completed a functional neuroimaging emotion regulation task. In the middle of the task, participants were socially rejected by an unfamiliar confederate whom the participants had elected to meet. Participants also completed a multimethod STB assessment. Results: Before rejection, girls with a history of STBs, compared with control participants, showed greater activation in the right superior frontal gyrus when passively viewing negative stimuli, and girls with suicidal behavior (SB) versus those without SB showed less activation in the right frontal pole during emotion regulation attempts. Following the rejection, girls with STBs, compared with control participants, showed greater activation in the right inferior frontal gyrus during emotion regulation. Conclusions: Before social rejection, girls with SB versus without SB may not activate brain regions implicated in emotion regulation, suggesting a vulnerability to poor regulation at their baseline emotional state. After social rejection, girls with any history of STBs showed altered activation in a brain region strongly associated with inhibition and emotion regulation success, possibly reflecting increased effort at inhibiting emotional responses during regulation following stress exposure.
KW - Adolescent suicide risk
KW - Emotion processing
KW - Functional neuroimaging
KW - Interpersonal stress
KW - Suicidal thoughts
KW - Suicide attempts
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UR - http://www.scopus.com/inward/citedby.url?scp=85180470214&partnerID=8YFLogxK
U2 - 10.1016/j.biopsych.2023.10.015
DO - 10.1016/j.biopsych.2023.10.015
M3 - Article
C2 - 37918460
AN - SCOPUS:85180470214
SN - 0006-3223
VL - 95
SP - 1100
EP - 1109
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 12
ER -