Neural correlates of high-risk behavior tendencies and impulsivity in an emotional Go/NoGo fMRI task

Matthew R.G. Brown, James R.A. Benoit, Michal Juhás, R. M. Lebel, Marnie MacKay, Ericson Dametto, Peter H. Silverstone, Florin Dolcos, Serdar M. Dursun, Andrew J. Greenshaw

Research output: Contribution to journalArticle

Abstract

Improved neuroscientific understanding of high-risk behaviors such as alcohol binging, drug use, and unsafe sex will lead to therapeutic advances for high-risk groups. High-risk behavior often occurs in an emotionally-charged context, and behavioral inhibition and emotion regulation play important roles in risk-related decision making. High impulsivity is an important potential contributor to high-risk behavior tendencies. We explored the relationships between high-risk behavior tendencies, impulsivity, and fMRI brain activations in an emotional Go/NoGo task. This task presented emotional distractor pictures (aversive vs. neutral) simultaneously with Go/NoGo stimuli (square vs. circle) that required a button press or withholding of the press, respectively. Participants' risk behavior tendencies were assessed with the Cognitive Appraisal of Risky Events (CARE) scale. The Barratt Impulsivity Scale 11 (BIS) was used to assess participant impulsivity. Individuals with higher CARE risk scores exhibited reduced activation related to response inhibition (NoGo−Go) in right orbital frontal cortex (OFC) and ventromedial prefrontal cortex. These regions did not show a significant relationship with impulsivity scores. Conversely, more impulsive individuals showed reduced emotion-related activity (aversive−neutral distractors) in dorsomedial prefrontal cortex, perigenual anterior cingulate cortex, and right posterior OFC. There were distinct neural correlates of high-risk behavior tendency and impulsivity in terms of brain activity in the emotional Go/NoGo task. This dissociation supports the conception of high-risk behavior tendency as a distinct construct from that of impulsivity. Our results suggest that treatment for high-risk behavior may be more effective with a nuanced approach that does not conflate high impulsivity necessarily with high-risk behavior tendencies.

Original languageEnglish (US)
Article number24
Pages (from-to)1-24
Number of pages24
JournalFrontiers in Systems Neuroscience
Volume9
Issue numberMar
DOIs
StatePublished - Mar 10 2015

Fingerprint

Impulsive Behavior
Risk-Taking
Magnetic Resonance Imaging
Prefrontal Cortex
Frontal Lobe
Emotions
Unsafe Sex
Gyrus Cinguli
Brain
Decision Making
Alcohols

Keywords

  • Bis
  • Care
  • Emotional go/nogo
  • Fmri
  • High-risk behavior
  • Impulsivity

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Developmental Neuroscience
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Brown, M. R. G., Benoit, J. R. A., Juhás, M., Lebel, R. M., MacKay, M., Dametto, E., ... Greenshaw, A. J. (2015). Neural correlates of high-risk behavior tendencies and impulsivity in an emotional Go/NoGo fMRI task. Frontiers in Systems Neuroscience, 9(Mar), 1-24. [24]. https://doi.org/10.3389/fnsys.2015.00024

Neural correlates of high-risk behavior tendencies and impulsivity in an emotional Go/NoGo fMRI task. / Brown, Matthew R.G.; Benoit, James R.A.; Juhás, Michal; Lebel, R. M.; MacKay, Marnie; Dametto, Ericson; Silverstone, Peter H.; Dolcos, Florin; Dursun, Serdar M.; Greenshaw, Andrew J.

In: Frontiers in Systems Neuroscience, Vol. 9, No. Mar, 24, 10.03.2015, p. 1-24.

Research output: Contribution to journalArticle

Brown, MRG, Benoit, JRA, Juhás, M, Lebel, RM, MacKay, M, Dametto, E, Silverstone, PH, Dolcos, F, Dursun, SM & Greenshaw, AJ 2015, 'Neural correlates of high-risk behavior tendencies and impulsivity in an emotional Go/NoGo fMRI task', Frontiers in Systems Neuroscience, vol. 9, no. Mar, 24, pp. 1-24. https://doi.org/10.3389/fnsys.2015.00024
Brown, Matthew R.G. ; Benoit, James R.A. ; Juhás, Michal ; Lebel, R. M. ; MacKay, Marnie ; Dametto, Ericson ; Silverstone, Peter H. ; Dolcos, Florin ; Dursun, Serdar M. ; Greenshaw, Andrew J. / Neural correlates of high-risk behavior tendencies and impulsivity in an emotional Go/NoGo fMRI task. In: Frontiers in Systems Neuroscience. 2015 ; Vol. 9, No. Mar. pp. 1-24.
@article{47872fca5422453799f5e88d4bfd0d62,
title = "Neural correlates of high-risk behavior tendencies and impulsivity in an emotional Go/NoGo fMRI task",
abstract = "Improved neuroscientific understanding of high-risk behaviors such as alcohol binging, drug use, and unsafe sex will lead to therapeutic advances for high-risk groups. High-risk behavior often occurs in an emotionally-charged context, and behavioral inhibition and emotion regulation play important roles in risk-related decision making. High impulsivity is an important potential contributor to high-risk behavior tendencies. We explored the relationships between high-risk behavior tendencies, impulsivity, and fMRI brain activations in an emotional Go/NoGo task. This task presented emotional distractor pictures (aversive vs. neutral) simultaneously with Go/NoGo stimuli (square vs. circle) that required a button press or withholding of the press, respectively. Participants' risk behavior tendencies were assessed with the Cognitive Appraisal of Risky Events (CARE) scale. The Barratt Impulsivity Scale 11 (BIS) was used to assess participant impulsivity. Individuals with higher CARE risk scores exhibited reduced activation related to response inhibition (NoGo−Go) in right orbital frontal cortex (OFC) and ventromedial prefrontal cortex. These regions did not show a significant relationship with impulsivity scores. Conversely, more impulsive individuals showed reduced emotion-related activity (aversive−neutral distractors) in dorsomedial prefrontal cortex, perigenual anterior cingulate cortex, and right posterior OFC. There were distinct neural correlates of high-risk behavior tendency and impulsivity in terms of brain activity in the emotional Go/NoGo task. This dissociation supports the conception of high-risk behavior tendency as a distinct construct from that of impulsivity. Our results suggest that treatment for high-risk behavior may be more effective with a nuanced approach that does not conflate high impulsivity necessarily with high-risk behavior tendencies.",
keywords = "Bis, Care, Emotional go/nogo, Fmri, High-risk behavior, Impulsivity",
author = "Brown, {Matthew R.G.} and Benoit, {James R.A.} and Michal Juh{\'a}s and Lebel, {R. M.} and Marnie MacKay and Ericson Dametto and Silverstone, {Peter H.} and Florin Dolcos and Dursun, {Serdar M.} and Greenshaw, {Andrew J.}",
year = "2015",
month = "3",
day = "10",
doi = "10.3389/fnsys.2015.00024",
language = "English (US)",
volume = "9",
pages = "1--24",
journal = "Frontiers in Systems Neuroscience",
issn = "1662-5137",
publisher = "Frontiers Research Foundation",
number = "Mar",

}

TY - JOUR

T1 - Neural correlates of high-risk behavior tendencies and impulsivity in an emotional Go/NoGo fMRI task

AU - Brown, Matthew R.G.

AU - Benoit, James R.A.

AU - Juhás, Michal

AU - Lebel, R. M.

AU - MacKay, Marnie

AU - Dametto, Ericson

AU - Silverstone, Peter H.

AU - Dolcos, Florin

AU - Dursun, Serdar M.

AU - Greenshaw, Andrew J.

PY - 2015/3/10

Y1 - 2015/3/10

N2 - Improved neuroscientific understanding of high-risk behaviors such as alcohol binging, drug use, and unsafe sex will lead to therapeutic advances for high-risk groups. High-risk behavior often occurs in an emotionally-charged context, and behavioral inhibition and emotion regulation play important roles in risk-related decision making. High impulsivity is an important potential contributor to high-risk behavior tendencies. We explored the relationships between high-risk behavior tendencies, impulsivity, and fMRI brain activations in an emotional Go/NoGo task. This task presented emotional distractor pictures (aversive vs. neutral) simultaneously with Go/NoGo stimuli (square vs. circle) that required a button press or withholding of the press, respectively. Participants' risk behavior tendencies were assessed with the Cognitive Appraisal of Risky Events (CARE) scale. The Barratt Impulsivity Scale 11 (BIS) was used to assess participant impulsivity. Individuals with higher CARE risk scores exhibited reduced activation related to response inhibition (NoGo−Go) in right orbital frontal cortex (OFC) and ventromedial prefrontal cortex. These regions did not show a significant relationship with impulsivity scores. Conversely, more impulsive individuals showed reduced emotion-related activity (aversive−neutral distractors) in dorsomedial prefrontal cortex, perigenual anterior cingulate cortex, and right posterior OFC. There were distinct neural correlates of high-risk behavior tendency and impulsivity in terms of brain activity in the emotional Go/NoGo task. This dissociation supports the conception of high-risk behavior tendency as a distinct construct from that of impulsivity. Our results suggest that treatment for high-risk behavior may be more effective with a nuanced approach that does not conflate high impulsivity necessarily with high-risk behavior tendencies.

AB - Improved neuroscientific understanding of high-risk behaviors such as alcohol binging, drug use, and unsafe sex will lead to therapeutic advances for high-risk groups. High-risk behavior often occurs in an emotionally-charged context, and behavioral inhibition and emotion regulation play important roles in risk-related decision making. High impulsivity is an important potential contributor to high-risk behavior tendencies. We explored the relationships between high-risk behavior tendencies, impulsivity, and fMRI brain activations in an emotional Go/NoGo task. This task presented emotional distractor pictures (aversive vs. neutral) simultaneously with Go/NoGo stimuli (square vs. circle) that required a button press or withholding of the press, respectively. Participants' risk behavior tendencies were assessed with the Cognitive Appraisal of Risky Events (CARE) scale. The Barratt Impulsivity Scale 11 (BIS) was used to assess participant impulsivity. Individuals with higher CARE risk scores exhibited reduced activation related to response inhibition (NoGo−Go) in right orbital frontal cortex (OFC) and ventromedial prefrontal cortex. These regions did not show a significant relationship with impulsivity scores. Conversely, more impulsive individuals showed reduced emotion-related activity (aversive−neutral distractors) in dorsomedial prefrontal cortex, perigenual anterior cingulate cortex, and right posterior OFC. There were distinct neural correlates of high-risk behavior tendency and impulsivity in terms of brain activity in the emotional Go/NoGo task. This dissociation supports the conception of high-risk behavior tendency as a distinct construct from that of impulsivity. Our results suggest that treatment for high-risk behavior may be more effective with a nuanced approach that does not conflate high impulsivity necessarily with high-risk behavior tendencies.

KW - Bis

KW - Care

KW - Emotional go/nogo

KW - Fmri

KW - High-risk behavior

KW - Impulsivity

UR - http://www.scopus.com/inward/record.url?scp=84961291414&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961291414&partnerID=8YFLogxK

U2 - 10.3389/fnsys.2015.00024

DO - 10.3389/fnsys.2015.00024

M3 - Article

AN - SCOPUS:84961291414

VL - 9

SP - 1

EP - 24

JO - Frontiers in Systems Neuroscience

JF - Frontiers in Systems Neuroscience

SN - 1662-5137

IS - Mar

M1 - 24

ER -