@inproceedings{4e827af17cb24074b884680d3059d7b7,
title = "Network based models and path based features for gene prioritization",
abstract = "Network analysis has been shown to be an effective and cheap way to screen genes that are associated to diseases and chemicals. The identification of features that are used to order potentially related genes is key to do this job. Though many network models and structure based features have been proposed in the literature, they do not perform well enough for such gene prioritization task, especially when the heterogeneity of such networks is taken account. In this paper, a type of heterogenous network called Generalized Bi-relational Network (GBN) is formalized. A series of path based features on GBN are defined. Though some of the features have been used in other literature, it is the first time to evaluate them in both supervised and unsupervised learning models. The experiment on real chemical-disease-gene networks shows that the features proposed in this paper gain promising performance in both supervised and unsupervised framework.",
keywords = "Generalized Bi-relation Network(GBN), feature, gene prioritization, network analysis, path",
author = "Yuechang Liu and Hanghang Tong and Xie Lei and Yong Tang",
note = "Funding Information: This material is supported by Jiaying University Grant (Collaboration Mechanism and Application in Social Networks), National Institutes of Health under the grant number R01LM011986. The content of the information in this document does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation here on. This work is also supported in part by the National High-Technology Research and Development Program (863 Program) of China under Grand 2013AA01A212, National Science Foundation Grant 61272067, 61370229 Publisher Copyright: {\textcopyright} 2016 IEEE.; 20th IEEE International Conference on Computer Supported Cooperative Work in Design, CSCWD 2016 ; Conference date: 04-05-2016 Through 06-05-2016",
year = "2016",
month = sep,
day = "13",
doi = "10.1109/CSCWD.2016.7565976",
language = "English (US)",
series = "Proceedings of the 2016 IEEE 20th International Conference on Computer Supported Cooperative Work in Design, CSCWD 2016",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "129--132",
editor = "Liu, {Xiaoping P.} and Jianming Yong and Jean-Paul Barthes and Weiming Shen and Chunsheng Yang and Junzhou Luo and Limin Chen",
booktitle = "Proceedings of the 2016 IEEE 20th International Conference on Computer Supported Cooperative Work in Design, CSCWD 2016",
address = "United States",
}