Nestin expression during mouse eye and lens development

Jing Yang, Wei Bian, Xiang Gao, Leping Chen, Naihe Jing

Research output: Contribution to journalArticlepeer-review


Nestin is an intermediate filament protein, which is expressed predominantly in the developing central nervous system and skeletal muscles. In situ hybridization revealed that mouse nestin mRNA is in the optic stalk at 9.0 days post coitus (dpc) and in the lens vesicle at 10.0 dpc. From 14.5 dpc onward, nestin transcripts appear in lens fibers and neuroretina. Immunohistochemistry showed that nestin protein appears in the optic stalk at 9.5 dpc and in the posterior lens epithelium at 10.5 dpc. By 12.5 dpc, it is found in the lens, neuroretina, and optic stalk as well as in developing extrinsic ocular muscle, and it localizes in lens epithelium, optic disc, and optic nerve from 14.5 dpc to postnatal day 1. In adult eye, nestin protein appears in the optic nerve. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)287-291
Number of pages5
JournalMechanisms of Development
Issue number1-2
StatePublished - Jun 1 2000
Externally publishedYes


  • Eye development
  • Lens epithelium
  • Lens fiber
  • Lens vesicle
  • Mouse
  • Nestin
  • Neuroretina
  • Optic nerve
  • Optic stalk

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology


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