Neonatal halothane anesthesia affects cortical morphology

Joseph L. Nuñez, Janice M. Juraska

Research output: Contribution to journalArticlepeer-review


Neonatal cryoanesthesia has recently been documented to affect morphology and behavior after a single exposure [Dev. Brain Res. 111 (1998) 89; Horm. Behav. 37 (2000) 169]. In the current experiment, we investigated the effect of one-time exposure to halothane inhalant anesthesia on neonatal rats of both sexes. Fifteen minutes of exposure on postnatal day one resulted in detectable changes in the volume of the visual cortex at 3 months. Thus, neonatal halothane alters neural development and its effects are observable in the adult rat. (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)121-124
Number of pages4
JournalDevelopmental Brain Research
Issue number1-2
StatePublished - Nov 30 2000


  • Development
  • Rat
  • Surgery

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology


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