Neonatal halothane anesthesia affects cortical morphology

Joseph L. Nuñez; Janice M. Juraska

doi:10.1016/S0165-3806(00)00093-6

Neonatal halothane anesthesia affects cortical morphology

Research output: Contribution to journal › Article › peer-review

Abstract

Neonatal cryoanesthesia has recently been documented to affect morphology and behavior after a single exposure [Dev. Brain Res. 111 (1998) 89; Horm. Behav. 37 (2000) 169]. In the current experiment, we investigated the effect of one-time exposure to halothane inhalant anesthesia on neonatal rats of both sexes. Fifteen minutes of exposure on postnatal day one resulted in detectable changes in the volume of the visual cortex at 3 months. Thus, neonatal halothane alters neural development and its effects are observable in the adult rat. (C) 2000 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	121-124
Number of pages	4
Journal	Developmental Brain Research
Volume	124
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-3806(00)00093-6
State	Published - Nov 30 2000

Keywords

Development
Rat
Surgery

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

Online availability

10.1016/S0165-3806(00)00093-6

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N2 - Neonatal cryoanesthesia has recently been documented to affect morphology and behavior after a single exposure [Dev. Brain Res. 111 (1998) 89; Horm. Behav. 37 (2000) 169]. In the current experiment, we investigated the effect of one-time exposure to halothane inhalant anesthesia on neonatal rats of both sexes. Fifteen minutes of exposure on postnatal day one resulted in detectable changes in the volume of the visual cortex at 3 months. Thus, neonatal halothane alters neural development and its effects are observable in the adult rat. (C) 2000 Elsevier Science B.V.

AB - Neonatal cryoanesthesia has recently been documented to affect morphology and behavior after a single exposure [Dev. Brain Res. 111 (1998) 89; Horm. Behav. 37 (2000) 169]. In the current experiment, we investigated the effect of one-time exposure to halothane inhalant anesthesia on neonatal rats of both sexes. Fifteen minutes of exposure on postnatal day one resulted in detectable changes in the volume of the visual cortex at 3 months. Thus, neonatal halothane alters neural development and its effects are observable in the adult rat. (C) 2000 Elsevier Science B.V.

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Neonatal halothane anesthesia affects cortical morphology

Abstract

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