Neonatal alloimmune thrombocytopenia in a quarter horse foal.

V. Buechner-Maxwell, M. A. Scott, L. Godber, A. Kristensen

Research output: Contribution to journalArticlepeer-review


Neonatal alloimmune thrombocytopenia is recognized as a spontaneous disease of human infants, piglets, and possibly mules, but it has not been previously reported in horses. A 1-day-old Quarter Horse foal presented to Michigan State University Large Animal Clinic with severe thrombocytopenia of unknown origin. Immunoglobulins that bound to the foal's platelets were identified in the mare's plasma, serum, and milk by indirect assays. The immunoglobulins were further shown to recognize platelets from the foal's full brother, born 1 year earlier. These findings, coupled with the clinical course of the foal during its period of hospitalization, strongly suggest that neonatal alloimmune thrombocytopenia can spontaneously occur in neonatal horses. This diagnosis should be considered for foals with severe thrombocytopenia when other causes can be excluded, and platelet antibody assays should be used to support this diagnosis.

Original languageEnglish (US)
Pages (from-to)304-308
Number of pages5
JournalJournal of veterinary internal medicine / American College of Veterinary Internal Medicine
Issue number5
StatePublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • veterinary(all)

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