Neither intact nor hydrolyzed soy proteins elicit intestinal inflammation in neonatal piglets

Barbara A. Mcuracken, Ruurd T. Zijlstra, Sharon M. Donovax, Jack Odle, Eric L. Lien, H. Rex Gaskins

Research output: Contribution to journalArticle

Abstract

Background: Efficacy of feeding hydrolyzed soy proteins to infants intolerant to cow milk proteins has not been determined fully. This study compared growth and intestinal responses of neonatal piglets fed formulas with hydrolyzed soy protein to piglets fed formulas with intact soy or cow milk (casein-whey) proteins. Methods: Piglets (n = 40, day 2 postpartum) were fed commercial milk replacer until day 7 postpartum (designated day 0) and then were assigned randomly to casein-whey (CW) or soy (intact, SI; hydrolyzed, SH) formulas to evaluate intestinal responses on days 0, 2, 5, and 10. Results: Average daily gain was higher for CW (121 g/d; p < .05) compared with SI piglets (85 g/d); SH pig weight gain was intermediate (109 g/d). Villus height-to-crypt depth ratio in proximal jejunum was lower (p < .05) on day 2 than day 0 in soy-fed pigs and lower (p < .05) on day 5 than day 0 in CW pigs. Mucosal mast cells were generally higher in CW pigs compared with soy-fed pigs. Villus goblet cell numbers in the midjejunum of SH-fed piglets were lower (p < .05) on day 5 compared with day 0. On day 5, crypt goblet cell numbers were higher (p < .05) in the midjejunum of CW-fed piglets compared with SH-fed piglets with numbers intermediate for SI-fed piglets. Intestinal differences were not detected among dietary treatments for major histocompatibility complex class I and II gene expression, tissue concentrations of prostaglandin E2, or CD8+ T-cell numbers. Conclusions: Hydrolyzed soy proteins do not elicit intestinal inflammatory responses in piglets and may be viable alternatives to milk and intact soy proteins for feeding infants.

Original languageEnglish (US)
Pages (from-to)91-97
Number of pages7
JournalJournal of Parenteral and Enteral Nutrition
Volume22
Issue number2
StatePublished - Mar 26 1998

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Soybean Proteins
Caseins
Inflammation
Swine
Milk
Goblet Cells
Cell Count
Postpartum Period
MHC Class I Genes
MHC Class II Genes
Milk Proteins
Jejunum
Major Histocompatibility Complex
Dinoprostone
Mast Cells
Weight Gain
Whey
T-Lymphocytes
Gene Expression
Growth

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Neither intact nor hydrolyzed soy proteins elicit intestinal inflammation in neonatal piglets. / Mcuracken, Barbara A.; Zijlstra, Ruurd T.; Donovax, Sharon M.; Odle, Jack; Lien, Eric L.; Rex Gaskins, H.

In: Journal of Parenteral and Enteral Nutrition, Vol. 22, No. 2, 26.03.1998, p. 91-97.

Research output: Contribution to journalArticle

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abstract = "Background: Efficacy of feeding hydrolyzed soy proteins to infants intolerant to cow milk proteins has not been determined fully. This study compared growth and intestinal responses of neonatal piglets fed formulas with hydrolyzed soy protein to piglets fed formulas with intact soy or cow milk (casein-whey) proteins. Methods: Piglets (n = 40, day 2 postpartum) were fed commercial milk replacer until day 7 postpartum (designated day 0) and then were assigned randomly to casein-whey (CW) or soy (intact, SI; hydrolyzed, SH) formulas to evaluate intestinal responses on days 0, 2, 5, and 10. Results: Average daily gain was higher for CW (121 g/d; p < .05) compared with SI piglets (85 g/d); SH pig weight gain was intermediate (109 g/d). Villus height-to-crypt depth ratio in proximal jejunum was lower (p < .05) on day 2 than day 0 in soy-fed pigs and lower (p < .05) on day 5 than day 0 in CW pigs. Mucosal mast cells were generally higher in CW pigs compared with soy-fed pigs. Villus goblet cell numbers in the midjejunum of SH-fed piglets were lower (p < .05) on day 5 compared with day 0. On day 5, crypt goblet cell numbers were higher (p < .05) in the midjejunum of CW-fed piglets compared with SH-fed piglets with numbers intermediate for SI-fed piglets. Intestinal differences were not detected among dietary treatments for major histocompatibility complex class I and II gene expression, tissue concentrations of prostaglandin E2, or CD8+ T-cell numbers. Conclusions: Hydrolyzed soy proteins do not elicit intestinal inflammatory responses in piglets and may be viable alternatives to milk and intact soy proteins for feeding infants.",
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AU - Rex Gaskins, H.

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