Needle-probe system for the measurement of tissue refractive index

Adam M. Zysk, Steven G. Adie, Julian J. Armstrong, Matthew S. Leigh, Alexandre Paduch, Freddy T. Nguyen, David D. Sampson, Stephen A. Boppart

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Needle-based devices, which are in wide clinical use for needle biopsy procedures, may be augmented by suitable optical techniques for the localization and diagnosis of diseased tissue. Tissue refractive index is one optical contrast mechanism with diagnostic potential. In the case of mammary tissue, for example, recent research indicates that refractive index variations between tissue types may be useful for the identification of cancerous tissue. While many coherence-based forward-sensing devices have been developed to detect scattering changes, none have demonstrated refractive index measurement capabilities. We present a novel needle-based device that is capable of simultaneously measuring refractive index and scattering. Coupled to the sample arm of an optical coherence tomography system, the needle device detects the scattering response and optical pathlength through tissue residing in a fixed-width channel. Near-infrared measurements of tissues and materials with known optical properties using a prototype device will be presented. This work demonstrates the feasibility of integrated in vivo measurement of refractive index and scattering in conjunction with existing clinical needle-based devices.

Original languageEnglish (US)
Title of host publicationAdvanced Biomedical and Clinical Diagnostic Systems V
DOIs
StatePublished - Apr 30 2007
EventAdvanced Biomedical and Clinical Diagnostic Systems V - San Jose, CA, United States
Duration: Jan 21 2007Jan 27 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6430
ISSN (Print)1605-7422

Other

OtherAdvanced Biomedical and Clinical Diagnostic Systems V
CountryUnited States
CitySan Jose, CA
Period1/21/071/27/07

Fingerprint

Needles
Refractive index
Tissue
Scattering
Biopsy
Optical tomography
Optical properties
Infrared radiation

Keywords

  • Fiber optic devices
  • Low coherence interferometry
  • Optical coherence tomography
  • Refractive index

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Zysk, A. M., Adie, S. G., Armstrong, J. J., Leigh, M. S., Paduch, A., Nguyen, F. T., ... Boppart, S. A. (2007). Needle-probe system for the measurement of tissue refractive index. In Advanced Biomedical and Clinical Diagnostic Systems V [64300O] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6430). https://doi.org/10.1117/12.700955

Needle-probe system for the measurement of tissue refractive index. / Zysk, Adam M.; Adie, Steven G.; Armstrong, Julian J.; Leigh, Matthew S.; Paduch, Alexandre; Nguyen, Freddy T.; Sampson, David D.; Boppart, Stephen A.

Advanced Biomedical and Clinical Diagnostic Systems V. 2007. 64300O (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6430).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Zysk, AM, Adie, SG, Armstrong, JJ, Leigh, MS, Paduch, A, Nguyen, FT, Sampson, DD & Boppart, SA 2007, Needle-probe system for the measurement of tissue refractive index. in Advanced Biomedical and Clinical Diagnostic Systems V., 64300O, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 6430, Advanced Biomedical and Clinical Diagnostic Systems V, San Jose, CA, United States, 1/21/07. https://doi.org/10.1117/12.700955
Zysk AM, Adie SG, Armstrong JJ, Leigh MS, Paduch A, Nguyen FT et al. Needle-probe system for the measurement of tissue refractive index. In Advanced Biomedical and Clinical Diagnostic Systems V. 2007. 64300O. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.700955
Zysk, Adam M. ; Adie, Steven G. ; Armstrong, Julian J. ; Leigh, Matthew S. ; Paduch, Alexandre ; Nguyen, Freddy T. ; Sampson, David D. ; Boppart, Stephen A. / Needle-probe system for the measurement of tissue refractive index. Advanced Biomedical and Clinical Diagnostic Systems V. 2007. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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