Near ultraviolet-wavelength photonic-crystal biosensor with enhanced surface-to-bulk sensitivity ratio

Nikhil Ganesh; Ian D. Block; Brian T. Cunningham

doi:10.1063/1.2219984

Near ultraviolet-wavelength photonic-crystal biosensor with enhanced surface-to-bulk sensitivity ratio

Nikhil Ganesh
, Ian D. Block
, Brian T. Cunningham

Research output: Contribution to journal › Article › peer-review

Abstract

We report the design and characterization of biosensors based on one-dimensional photonic-crystal reflectance filters operating at near-ultraviolet wavelengths. Rigorous coupled-wave analysis simulations predict an increased confinement of the resonant electric field at the surface of this biosensor as compared to previously fabricated near-infrared photonic-crystal biosensors. This change in the resonant electric field provides an improvement of over 4.5 times in the surface-sensitivity to bulk-sensitivity ratio, and therefore enables enhanced detection resolution for biomolecules adsorbed on the biosensor surface. These biosensors will be especially important for applications requiring the detection of small molecules or ultralow analyte concentrations.

Original language	English (US)
Article number	023901
Journal	Applied Physics Letters
Volume	89
Issue number	2
DOIs	https://doi.org/10.1063/1.2219984
State	Published - 2006

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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10.1063/1.2219984

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title = "Near ultraviolet-wavelength photonic-crystal biosensor with enhanced surface-to-bulk sensitivity ratio",

abstract = "We report the design and characterization of biosensors based on one-dimensional photonic-crystal reflectance filters operating at near-ultraviolet wavelengths. Rigorous coupled-wave analysis simulations predict an increased confinement of the resonant electric field at the surface of this biosensor as compared to previously fabricated near-infrared photonic-crystal biosensors. This change in the resonant electric field provides an improvement of over 4.5 times in the surface-sensitivity to bulk-sensitivity ratio, and therefore enables enhanced detection resolution for biomolecules adsorbed on the biosensor surface. These biosensors will be especially important for applications requiring the detection of small molecules or ultralow analyte concentrations.",

author = "Nikhil Ganesh and Block, \{Ian D.\} and Cunningham, \{Brian T.\}",

note = "This work was supported by the University of Illinois College of ACES Experimental Station, SRU Biosystems, the Soybean Disease Biotechnology Center, and the National Science Foundation (BES 0427657). The authors would also like to thank the staff of the Micro and Nanotechnology Laboratory and colleagues from the Nano Sensors Group for their valuable suggestions and input.",

year = "2006",

doi = "10.1063/1.2219984",

language = "English (US)",

volume = "89",

journal = "Applied Physics Letters",

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publisher = "American Institute of Physics",

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AU - Ganesh, Nikhil

AU - Block, Ian D.

AU - Cunningham, Brian T.

N1 - This work was supported by the University of Illinois College of ACES Experimental Station, SRU Biosystems, the Soybean Disease Biotechnology Center, and the National Science Foundation (BES 0427657). The authors would also like to thank the staff of the Micro and Nanotechnology Laboratory and colleagues from the Nano Sensors Group for their valuable suggestions and input.

PY - 2006

Y1 - 2006

N2 - We report the design and characterization of biosensors based on one-dimensional photonic-crystal reflectance filters operating at near-ultraviolet wavelengths. Rigorous coupled-wave analysis simulations predict an increased confinement of the resonant electric field at the surface of this biosensor as compared to previously fabricated near-infrared photonic-crystal biosensors. This change in the resonant electric field provides an improvement of over 4.5 times in the surface-sensitivity to bulk-sensitivity ratio, and therefore enables enhanced detection resolution for biomolecules adsorbed on the biosensor surface. These biosensors will be especially important for applications requiring the detection of small molecules or ultralow analyte concentrations.

AB - We report the design and characterization of biosensors based on one-dimensional photonic-crystal reflectance filters operating at near-ultraviolet wavelengths. Rigorous coupled-wave analysis simulations predict an increased confinement of the resonant electric field at the surface of this biosensor as compared to previously fabricated near-infrared photonic-crystal biosensors. This change in the resonant electric field provides an improvement of over 4.5 times in the surface-sensitivity to bulk-sensitivity ratio, and therefore enables enhanced detection resolution for biomolecules adsorbed on the biosensor surface. These biosensors will be especially important for applications requiring the detection of small molecules or ultralow analyte concentrations.

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JF - Applied Physics Letters

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Near ultraviolet-wavelength photonic-crystal biosensor with enhanced surface-to-bulk sensitivity ratio

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